Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TGM2 | P21980 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1699791 | 0.88 | SMN1; SMN2 (0.88) | LMNASMN1; SMN2HTTL3MBTL1MAPT | |
| SCHEMBL21069701 | 0.86 | SMN1; SMN2 (0.85) | LMNASMN1; SMN2HTTL3MBTL1MAPT | |
| SCHEMBL21071132 | 0.86 | SMN1; SMN2 (0.85) | LMNASMN1; SMN2HTTL3MBTL1MAPT | |
| SCHEMBL6759604 | 0.86 | SMN1; SMN2 (0.85) | LMNASMN1; SMN2HTTL3MBTL1MAPT | |
| SCHEMBL21069619 | 0.86 | SMN1; SMN2 (0.85) | LMNASMN1; SMN2HTTL3MBTL1MAPT | |
| SCHEMBL15745846 | 0.86 | SMN1; SMN2 (0.65) | LMNASMN1; SMN2HTTALDH1A1L3MBTL1 | |
| SCHEMBL15745845 | 0.84 | SMN1; SMN2 (0.62) | LMNASMN1; SMN2HTTALDH1A1L3MBTL1 | |
| SCHEMBL5529923 | 0.82 | LMNA (0.68) | LMNASMN1; SMN2HTTL3MBTL1MAPT | |
| SCHEMBL375858 | 0.81 | LMNA (0.73) | LMNASMN1; SMN2HTTALDH1A1L3MBTL1 | |
| SCHEMBL250620 | 0.81 | LMNA (0.67) | LMNASMN1; SMN2HTTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016162325-A1 | SUBSTITUTED 3,4-DIHYDROPYRROLO[1,2-A]PYRAZIN-1 (2H)-ONE DERIVATIVES AS KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2016-10-13 | — | — | WO | disclosed |