Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 17/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 12/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 9/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 9/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | INSR | P06213 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 2/20 | 0.33 |
| ▸ | FYN | P06241 | 2/20 | 0.33 |
| ▸ | YES1 | P07947 | 2/20 | 0.33 |
| ▸ | LYN | P07948 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 2/20 | 0.33 |
| ▸ | ROS1 | P08922 | 2/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18131100 | 0.83 | FGFR1 (0.52) | FGFR1FGFR4FGFR3FGFR2CYP3A4 | |
| SCHEMBL18131211 | 0.78 | FGFR3 (0.38) | FGFR1FGFR4FGFR3FGFR2CYP3A4 | |
| SCHEMBL18138288 | 0.75 | FGFR3 (0.36) | FGFR1FGFR4FGFR3FGFR2CYP3A4 | |
| SCHEMBL17740810 | 0.71 | FGFR1 (0.73) | FGFR1FGFR4FGFR3FGFR2CYP3A4 | |
| SCHEMBL16654119 | 0.71 | FGFR3 (0.35) | FGFR1FGFR4FGFR3FGFR2CYP3A4 | |
| SCHEMBL18153620 | 0.69 | FGFR1 (0.73) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL16659627 | 0.67 | FGFR3 (0.33) | FGFR1FGFR4FGFR3FGFR2CYP3A4 | |
| SCHEMBL28767434 | 0.67 | FGFR1 (0.33) | FGFR1FGFR4FGFR3FGFR2CYP3A4 | |
| SCHEMBL18153622 | 0.66 | FGFR1 (0.57) | FGFR1FGFR4FGFR3FGFR2JAK2 | |
| SCHEMBL28767438 | 0.66 | FGFR3 (0.42) | FGFR1FGFR4FGFR3FGFR2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164754-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |