Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.74 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.65 |
| ▸ | RARB | P10826 | 3/20 | 0.58 |
| ▸ | RARG | P13631 | 3/20 | 0.58 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 2/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | RARA | P10276 | 2/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | RXRB | P28702 | 1/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL69572 | 0.89 | RARB (0.69) | TSHRALOX15SRD5A2RARBRARG | |
| SCHEMBL29789030 | 0.89 | RARB (0.69) | TSHRALOX15SRD5A2RARBRARG | |
| Hydrochloric Acid SCHEMBL5666955 | 0.86 | RARB (0.67) | TSHRALOX15SRD5A2RARBRARG | |
| 4-Chloro-Benzoic Acid SCHEMBL28384 | 0.86 | TSHR (1.00) | TSHRALOX15SRD5A2ALDH1A1NR4A2 | |
| 4-Chloro-Benzoic Acid SCHEMBL1331727 | 0.86 | TSHR (1.00) | TSHRALOX15SRD5A2ALDH1A1NR4A2 | |
| 4-Chloro-Benzoic Acid SCHEMBL9493329 | 0.84 | TSHR (0.94) | TSHRALOX15SRD5A2ALDH1A1NR4A2 | |
| 4-Chloro-Benzoic Acid SCHEMBL8024007 | 0.84 | TSHR (0.94) | TSHRALOX15SRD5A2ALDH1A1NR4A2 | |
| 4-Chloro-Benzoic Acid SCHEMBL3150134 | 0.84 | TSHR (0.94) | TSHRALOX15SRD5A2ALDH1A1NR4A2 | |
| 4-Chloro-Benzoic Acid SCHEMBL2918294 | 0.84 | TSHR (0.94) | TSHRALOX15SRD5A2ALDH1A1NR4A2 | |
| 4-Chloro-Benzoic Acid SCHEMBL9316886 | 0.84 | TSHR (0.94) | TSHRALOX15SRD5A2ALDH1A1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1997638-B | 1,1' - (1, 2-acetylenediyl) bis-benzene derivatives as PTP1-B inhibitors | APPLIED RESEARCH SYSTEMS | 2011-07-06 | — | — | CN | disclosed |
| US-7947851-B2 | 1,1′-(1,2-ethynediyl)bis-benzene derivatives as PTP 1-B inhibitors | MERCK SERONO SA (CH) | 2011-05-24 | — | — | US | disclosed |
| US-7947851-B2 | 1,1′-(1,2-ethynediyl)bis-benzene derivatives as PTP 1-B inhibitors | MERCK SERONO SA (CH) | 2011-05-24 | — | — | US | disclosed |
| US-20090029903-A1 | 1,1'-(1,2-Ethynediyl)Bis-Benzene Derivatives As Ptp 1-B Inhibitors | MERCK SERONO SA (CH) | 2009-01-29 | — | — | US | disclosed |
| US-20090029903-A1 | 1,1'-(1,2-Ethynediyl)Bis-Benzene Derivatives As Ptp 1-B Inhibitors | MERCK SERONO SA (CH) | 2009-01-29 | — | — | US | disclosed |
| CN-1997638-A | 1, 1' - (1, 2-acetylenediyl) bis-benzene derivatives as PTP 1-B inhibitors | APPLIED RESEARCH SYSTEMS (AN) | 2007-07-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029903-A1 | 1,1'-(1,2-Ethynediyl)Bis-Benzene Derivatives As Ptp 1-B Inhibitors | PTPRS, PTPRZ1, PTP4A1 | TSHR 2008/4885ALOX15 1375/4885SRD5A2 304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.