Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14546468 | 0.87 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2HDAC1HDAC2HPGD | |
| SCHEMBL564869 | 0.86 | HPGD (0.44) | ALDH1A1SMN1; SMN2HDAC1HDAC2HPGD | |
| SCHEMBL21954020 | 0.82 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2HDAC1HDAC2HPGD | |
| SCHEMBL898975 | 0.80 | HDAC2 (0.47) | ALDH1A1SMN1; SMN2HDAC1HDAC2 | |
| SCHEMBL21727772 | 0.79 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2HDAC1HDAC2HPGD | |
| SCHEMBL29811281 | 0.78 | ALDH1A1 (0.73) | ALDH1A1SMN1; SMN2HDAC1HDAC2HPGD | |
| SCHEMBL98030 | 0.78 | ALDH1A1 (0.73) | ALDH1A1SMN1; SMN2HDAC1HDAC2HPGD | |
| SCHEMBL18510178 | 0.78 | HPGD (0.51) | ALDH1A1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL10031015 | 0.78 | HPGD (0.51) | ALDH1A1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL20034082 | 0.78 | HPGD (0.46) | ALDH1A1SMN1; SMN2HDAC1HDAC2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938350-B2 | Receptor tyrosine kinase-like orphan receptor 1 (ROR1) single chain Fv antibody fragment conjugates and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-04-10 | — | — | US | disclosed |
| US-20160304619-A1 | RECEPTOR TYROSINE KINASE-LIKE ORPHAN RECEPTOR 1 (ROR1) SINGLE CHAIN FV ANTIBODY FRAGMENT CONJUGATES AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-10-20 | — | — | US | disclosed |