Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | OXTR | P30559 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | ITGAL | P20701 | 1/20 | 0.32 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29386319 | 0.91 | — | — | |
| SCHEMBL730025 | 0.91 | — | — | |
| SCHEMBL8710 | 0.91 | — | — | |
| SCHEMBL6093132 | 0.91 | — | — | |
| Hydrochloric Acid SCHEMBL6762162 | 0.89 | MAOA (0.42) | MAOAMAOBNISCHCA1CA2 | |
| Methane SCHEMBL10528050 | 0.89 | MAOA (0.42) | MAOAMAOBNISCHCA1CA2 | |
| SCHEMBL3682309 | 0.89 | MAOA (0.42) | MAOAMAOBNISCHCA1CA2 | |
| Ammonia Solution, Strong SCHEMBL3205764 | 0.89 | MAOA (0.42) | MAOAMAOBNISCHCA1CA2 | |
| Piperazine SCHEMBL5564115 | 0.81 | HTR2C (0.43) | MAOAMAOBNISCHOXTRABCG2 | |
| SCHEMBL7234494 | 0.81 | ABCG2 (0.58) | MAOAMAOBNISCHOXTRABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402324-A1 | Benzodioxolylcyclopropylpiperazinylpyridazines | High Point Pharmaceuticals, LLC (US) | 2012-01-04 | — | — | EP | claimed |
| EP-2402324-A1 | Benzodioxolylcyclopropylpiperazinylpyridazines | High Point Pharmaceuticals, LLC (US) | 2012-01-04 | — | — | EP | disclosed |