Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | FLT1 | P17948 | 3/20 | 0.38 |
| ▸ | FLT4 | P35916 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18150249 | 0.68 | GAA (0.53) | ALDH1A1FLT1FLT4KDRGRIK1 | |
| SCHEMBL19329039 | 0.66 | DGAT1 (0.41) | ALDH1A1SMN1; SMN2GAANPC1LMNA | |
| SCHEMBL27779076 | 0.66 | ALDH1A1 (0.44) | ALDH1A1GAAKMT2ATSHRMAPT | |
| SCHEMBL12302451 | 0.64 | KDM4E (0.53) | GRIK1KMT2AACLYGPR35CASP1 | |
| SCHEMBL1009428 | 0.63 | — | — | |
| SCHEMBL30058200 | 0.63 | — | — | |
| SCHEMBL1196041 | 0.63 | KDM4E (0.50) | ALDH1A1GRIK1SMN1; SMN2GAANPC1 | |
| SCHEMBL11674451 | 0.62 | SMN1; SMN2 (0.55) | ALDH1A1FLT1FLT4KDRSMN1; SMN2 | |
| SCHEMBL5022620 | 0.61 | ALDH1A1 (0.53) | ALDH1A1NPC1LMNARAB9ATP53 | |
| SCHEMBL7871642 | 0.61 | SRD5A2 (0.70) | ALDH1A1FLT1FLT4KDRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294726-A1 | INDAZOLONES AS MODULATORS OF TNF SIGNALING | AbbVie Inc. (US) | 2018-03-21 | — | — | EP | disclosed |
| WO-2016168633-A1 | INDAZOLONES AS MODULATORS OF TNF SIGNALING | ABBVIE INC. (US) | 2016-10-20 | — | — | WO | disclosed |