Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.39 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16822 | 1.00 | SLC6A7 (0.49) | SLC6A7GPR119GRM1PANK3KCNH2 | |
| SCHEMBL18149492 | 0.89 | SLC6A7 (0.46) | SLC6A7GPR119GRM1PANK3KCNH2 | |
| SCHEMBL18145781 | 0.89 | SLC6A7 (0.46) | SLC6A7GPR119GRM1PANK3KCNH2 | |
| SCHEMBL18145782 | 0.89 | SLC6A7 (0.46) | SLC6A7GPR119GRM1PANK3KCNH2 | |
| SCHEMBL5476032 | 0.86 | SLC6A7 (0.49) | SLC6A7GPR119GRM1KCNH2SMO | |
| SCHEMBL18150922 | 0.85 | GPR119 (0.44) | SLC6A7GPR119GRM1KCNH2 | |
| SCHEMBL18150109 | 0.85 | GPR119 (0.44) | SLC6A7GPR119GRM1KCNH2 | |
| SCHEMBL18150110 | 0.85 | GPR119 (0.44) | SLC6A7GPR119GRM1KCNH2 | |
| SCHEMBL25232011 | 0.82 | AKR1C3 (0.45) | SLC6A7GRM1PANK3SMO | |
| SCHEMBL27233784 | 0.82 | SLC6A7 (0.46) | SLC6A7GPR119KCNH2SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294726-A1 | INDAZOLONES AS MODULATORS OF TNF SIGNALING | AbbVie Inc. (US) | 2018-03-21 | — | — | EP | disclosed |
| WO-2016168633-A1 | INDAZOLONES AS MODULATORS OF TNF SIGNALING | ABBVIE INC. (US) | 2016-10-20 | — | — | WO | disclosed |