SCHEMBL18152322

SCHEMBL18152322

NC(=O)OCCOc1ccc(C(=O)Nc2cccc(-c3ccc(Cl)c(F)c3)c2)cc1-c1ccc(F)cc1

nearest known ligand 0.82

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
BCL9 O00512 17/20 0.82
CTNNB1 P35222 17/20 0.82
KCNQ3 O43525 1/20 0.41
KCNQ2 O43526 1/20 0.41
KCNE1 P15382 1/20 0.41
KCNQ1 P51787 1/20 0.41
KCNQ5 Q9NR82 1/20 0.41
MET P08581 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18152394 0.97 BCL9 (0.82) BCL9CTNNB1KCNQ3KCNQ2KCNE1
SCHEMBL18152388 0.92 CTNNB1 (0.81) BCL9CTNNB1
SCHEMBL18152329 0.92 BCL9 (0.79) BCL9CTNNB1MET
SCHEMBL18165095 0.91 BCL9 (0.98) BCL9CTNNB1KCNQ3KCNQ2KCNE1
SCHEMBL18152471 0.90 BCL9 (0.82) BCL9CTNNB1
SCHEMBL18165094 0.89 BCL9 (0.98) BCL9CTNNB1KCNQ3KCNQ2KCNE1
SCHEMBL18152447 0.84 BCL9 (0.81) BCL9CTNNB1MET
SCHEMBL18165096 0.83 BCL9 (0.98) BCL9CTNNB1MET
SCHEMBL18165097 0.83 CTNNB1 (0.98) BCL9CTNNB1
SCHEMBL20021893 0.82 BCL9 (0.85) BCL9CTNNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016168524-A1 SUBSTITUTED N-([1,1'-BIPHENYL]-3-YL)-[1,1'-BIPHENYL]-3-CARBOXAMIDE ANALOGS AS INHIBITORS FOR BETA-CATENIN/B-CELL LYMPHOMA 9 INTERACTIONS UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2016-10-20 WO disclosed