SCHEMBL18152471

SCHEMBL18152471

NC(=O)OCCOc1ccc(C(=O)Nc2cccc(-c3ccc(F)cc3)c2)cc1-c1ccc(F)c(F)c1

nearest known ligand 0.82

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BCL9 O00512 20/20 0.82
CTNNB1 P35222 20/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18152388 0.97 CTNNB1 (0.81) BCL9CTNNB1
SCHEMBL18152329 0.94 BCL9 (0.79) BCL9CTNNB1
SCHEMBL18152394 0.92 BCL9 (0.82) BCL9CTNNB1
SCHEMBL18152322 0.90 BCL9 (0.82) BCL9CTNNB1
SCHEMBL18165097 0.88 CTNNB1 (0.98) BCL9CTNNB1
SCHEMBL18152447 0.87 BCL9 (0.81) BCL9CTNNB1
SCHEMBL18165096 0.85 BCL9 (0.98) BCL9CTNNB1
SCHEMBL18165094 0.83 BCL9 (0.98) BCL9CTNNB1
SCHEMBL18165149 0.81 CTNNB1 (0.98) BCL9CTNNB1
SCHEMBL18152395 0.81 CTNNB1 (1.00) BCL9CTNNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016168524-A1 SUBSTITUTED N-([1,1'-BIPHENYL]-3-YL)-[1,1'-BIPHENYL]-3-CARBOXAMIDE ANALOGS AS INHIBITORS FOR BETA-CATENIN/B-CELL LYMPHOMA 9 INTERACTIONS UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2016-10-20 WO disclosed