Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 2/20 | 0.36 |
| ▸ | CHUK | O15111 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18152492 | 0.82 | GRM2 (0.39) | PTGS1RORCMKNK1MKNK2KMT2A | |
| SCHEMBL20021930 | 0.78 | MPL (0.47) | PTGS1RORCCHEK2 | |
| SCHEMBL18152401 | 0.78 | PTGS1 (0.46) | PTGS1MKNK2CHEK2CA2MAP4K4 | |
| SCHEMBL18165202 | 0.78 | PSMD10 (0.41) | HTR2AHTR2CKCNH2DRD2IKBKB | |
| SCHEMBL18152509 | 0.77 | PTGS1 (0.45) | HTR2CPTGS1RORCKMT2ACHEK2 | |
| SCHEMBL18152489 | 0.76 | ROCK2 (0.36) | HTR2AHTR2CKCNH2IKBKBCHUK | |
| SCHEMBL10598218 | 0.75 | SNCA (0.39) | CA2 | |
| SCHEMBL18165201 | 0.74 | MAPK14 (0.52) | PTGS1RORCMKNK1MKNK2CHEK2 | |
| SCHEMBL18152554 | 0.71 | PTGS1 (0.40) | PTGS1MKNK2CHEK2MAP4K4 | |
| SCHEMBL778956 | 0.71 | PTGS2 (0.50) | PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016168524-A1 | SUBSTITUTED N-([1,1'-BIPHENYL]-3-YL)-[1,1'-BIPHENYL]-3-CARBOXAMIDE ANALOGS AS INHIBITORS FOR BETA-CATENIN/B-CELL LYMPHOMA 9 INTERACTIONS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2016-10-20 | — | — | WO | disclosed |