Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18152696 | 0.72 | RIPK1 (0.37) | HPGDMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL27917903 | 0.69 | CCNB2 (0.36) | HPGDGAAALDH1A1GRIN2BSMN1; SMN2 | |
| SCHEMBL3878066 | 0.64 | BCL2 (0.39) | KDM4EGAAMAPTMEN1ALDH1A1 | |
| SCHEMBL27936359 | 0.63 | IDH1 (0.38) | HPGDKDM4EGAAHSD17B10ALDH1A1 | |
| SCHEMBL10797942 | 0.63 | GRIN2B (0.42) | HPGDKDM4EHSD17B10MAPTMEN1 | |
| SCHEMBL27730994 | 0.61 | PNP (0.37) | KDM4EGAAMAPTALDH1A1GFER | |
| SCHEMBL27590499 | 0.60 | HCAR2 (0.39) | KDM4EMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL27917762 | 0.60 | PDE4A (0.38) | KDM4EGAAALDH1A1KMT2ALMNA | |
| SCHEMBL14953574 | 0.59 | TLR8 (0.42) | L3MBTL1 | |
| SCHEMBL30933259 | 0.58 | CYP3A4 (0.43) | GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283077-A2 | BROMODOMAIN INHIBITOR | Celgene Quanticel Research, Inc. (US) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016168682-A2 | BROMODOMAIN INHIBITOR | CELGENE QUANTICEL RESEARCH, INC. (US) | 2016-10-20 | — | — | WO | disclosed |