Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 1/20 | 0.52 |
| ▸ | PNLIP | P16233 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | USP28 | Q96RU2 | 2/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | FADS1 | O60427 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18152989 | 0.91 | NPC1 (0.50) | NPC1RAB9AMEN1KMT2APLAU | |
| SCHEMBL18152962 | 0.87 | JAK2 (0.42) | JAK2TYK2PNLIPNPC1RAB9A | |
| SCHEMBL121403 | 0.84 | JAK2 (0.54) | JAK2TYK2MEN1KMT2ANR1H4 | |
| SCHEMBL18153000 | 0.82 | SMN1; SMN2 (0.46) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL18153043 | 0.79 | HDAC1 (0.48) | NPC1RAB9AKMT2APLAUALDH1A1 | |
| SCHEMBL13602364 | 0.79 | RORC (0.59) | MEN1KMT2AALDH1A1MAPTRORC | |
| SCHEMBL27668330 | 0.78 | CYP3A4 (0.50) | JAK2TYK2MEN1KMT2AUSP28 | |
| SCHEMBL25395241 | 0.78 | JAK2 (0.65) | JAK2TYK2PNLIPNPC1RAB9A | |
| SCHEMBL29771435 | 0.76 | JAK2 (0.77) | JAK2TYK2PNLIPNPC1RAB9A | |
| SCHEMBL10427108 | 0.76 | JAK2 (0.77) | JAK2TYK2PNLIPNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283464-B1 | FACTOR XIA INHIBITORS | MERCK SHARP & DOHME (US) | 2019-10-23 | — | — | EP | disclosed |
| EP-3283464-A1 | FACTOR XIa INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016168098-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-10-20 | — | — | WO | disclosed |