Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.45 |
| ▸ | OXTR | P30559 | 1/20 | 0.45 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18152959 | 0.91 | JAK2 (0.52) | NPC1RAB9AKMT2AMEN1EPHX1 | |
| SCHEMBL13602364 | 0.87 | RORC (0.59) | KMT2AMEN1EPHX1EPHX2RORC | |
| SCHEMBL8280277 | 0.83 | NPC1 (0.71) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL18152943 | 0.81 | RAB9A (0.51) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL13602178 | 0.81 | RAB9A (0.56) | NPC1RAB9AKMT2AMAPK13MAPK12 | |
| SCHEMBL13602467 | 0.80 | L3MBTL1 (0.54) | NPC1RAB9AKMT2AMEN1EPHX2 | |
| SCHEMBL16285500 | 0.80 | RAB9A (0.56) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL1083471 | 0.79 | SMN1; SMN2 (0.65) | NPC1RAB9AKMT2AMEN1EPHX2 | |
| SCHEMBL13602191 | 0.79 | KMT2A (0.52) | NPC1RAB9AKMT2AMEN1EPHX1 | |
| SCHEMBL18152962 | 0.79 | JAK2 (0.42) | NPC1RAB9AKMT2AMEN1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180317-B1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME (US) | 2021-04-14 | — | — | EP | disclosed |
| EP-3283464-B1 | FACTOR XIA INHIBITORS | MERCK SHARP & DOHME (US) | 2019-10-23 | — | — | EP | disclosed |
| US-10081617-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-09-25 | — | — | US | disclosed |
| US-20180079743-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-03-22 | — | — | US | disclosed |
| EP-3283464-A1 | FACTOR XIa INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2018-02-21 | — | — | EP | disclosed |
| US-9868727-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-01-16 | — | — | US | disclosed |
| US-20170210732-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-07-27 | — | — | US | disclosed |
| WO-2016168098-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180079743-A1 | FACTOR XIa INHIBITORS | F11, F2, TFPI | NPC1 1229/4885RAB9A 1969/4885KMT2A 1103/4885 |
| US-20170210732-A1 | Factor XIa Inhibitors | F11, SERPINC1, TFPI | NPC1 1211/4885RAB9A 1961/4885KMT2A 1209/4885 |
| US-10081617-B2 | Factor XIa inhibitors | F11, F2, TFPI | NPC1 1229/4885RAB9A 1969/4885KMT2A 1103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.