Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | HTR2C | P28335 | 2/20 | 0.59 |
| ▸ | HTR2B | P41595 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29987788 | 1.00 | HTR2A (0.59) | HTR2AHTR2CHTR2BALDH1A1GAA | |
| SCHEMBL7679434 | 0.77 | ALDH1A1 (0.53) | HTR2AHTR2CHTR2BALDH1A1GAA | |
| SCHEMBL7818415 | 0.77 | AHR (0.57) | HTR2AHTR2CHTR2BALDH1A1GAA | |
| SCHEMBL5121758 | 0.76 | ALDH1A1 (0.68) | HTR2AHTR2CHTR2BALDH1A1GAA | |
| SCHEMBL7709727 | 0.76 | ALDH1A1 (0.68) | HTR2AHTR2CHTR2BALDH1A1GAA | |
| SCHEMBL7270310 | 0.76 | ALDH1A1 (0.68) | HTR2AHTR2CHTR2BALDH1A1GAA | |
| SCHEMBL5236954 | 0.76 | CDK4 (0.43) | HTR2AHTR2CHTR2BALDH1A1GAA | |
| SCHEMBL11377237 | 0.75 | HTR2A (0.57) | HTR2AHTR2CHTR2BALDH1A1HPGD | |
| SCHEMBL11380531 | 0.75 | HTR2C (1.00) | HTR2AHTR2CHTR2B | |
| SCHEMBL7580646 | 0.74 | POLB (0.56) | HTR2AALDH1A1GAAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286195-A1 | INDAZOLONES AS MODULATORS OF TNF SIGNALING | AbbVie Inc. (US) | 2018-02-28 | — | — | EP | claimed |
| WO-2016168638-A1 | INDAZOLONES AS MODULATORS OF TNF SIGNALING | ABBVIE INC. (US) | 2016-10-20 | — | — | WO | claimed |
| EP-4041262-A1 | TARGETED BIFUNCTIONAL DEGRADERS | Yale University (US) | 2022-08-17 | — | — | EP | disclosed |
| WO-2021072269-A1 | TARGETED BIFUNCTIONAL DEGRADERS | YALE UNIVERSITY (US) | 2021-04-15 | — | — | WO | disclosed |