Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 20/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18144953 | 0.88 | HRH3 (0.54) | HRH3CYP2D6KCNH2 | |
| SCHEMBL18144773 | 0.87 | HRH3 (0.58) | HRH3CYP2D6KCNH2 | |
| SCHEMBL11918450 | 0.84 | HRH3 (0.60) | HRH3CYP2D6KCNH2 | |
| SCHEMBL2175673 | 0.81 | RXRA (0.56) | — | |
| SCHEMBL12748875 | 0.80 | HRH3 (0.55) | HRH3CYP2D6KCNH2 | |
| SCHEMBL1468009 | 0.79 | HRH3 (0.65) | HRH3CYP2D6KCNH2 | |
| SCHEMBL18148313 | 0.79 | HRH3 (0.47) | HRH3CYP2D6KCNH2 | |
| SCHEMBL11918337 | 0.78 | HRH3 (0.56) | HRH3CYP2D6KCNH2 | |
| SCHEMBL18148482 | 0.78 | HRH3 (0.51) | HRH3CYP2D6KCNH2 | |
| SCHEMBL11918354 | 0.78 | HRH3 (0.55) | HRH3CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016168660-A1 | 3-SPIRO-7-HYDROXAMIC ACID TETRALINS AS HDAC INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2016-10-20 | — | — | WO | disclosed |