Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10075388 | 0.81 | RXRA (0.56) | RXRAALDH1A1KDM4EMAPTTDP1 | |
| SCHEMBL3880185 | 0.81 | RXRA (0.64) | RXRAALDH1A1KDM4EMAPTTDP1 | |
| SCHEMBL30195971 | 0.81 | RXRA (0.64) | RXRAALDH1A1KDM4EMAPTTDP1 | |
| SCHEMBL5322616 | 0.81 | RXRA (0.51) | RXRAGPR119EPHX2CYP2C9TRPM8 | |
| SCHEMBL18153948 | 0.81 | HRH3 (0.57) | — | |
| SCHEMBL4475359 | 0.77 | AKT1 (0.49) | EPHX2 | |
| SCHEMBL15156666 | 0.76 | GPR119 (0.70) | RXRAKMT2AGPR119EPHX2CYP2C9 | |
| SCHEMBL18144733 | 0.76 | RXRA (0.48) | RXRAALDH1A1KDM4EMAPTTDP1 | |
| SCHEMBL28840776 | 0.75 | EPHX2 (0.44) | KDM4EMAPTTDP1POLBBLM | |
| SCHEMBL28840694 | 0.74 | EPHX2 (0.43) | KDM4EMAPTTDP1POLBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973047-B2 | Beta-Secretase modulators and methods of use | AMGEN INC. (US) | 2011-07-05 | — | — | US | disclosed |