Guanine

Guanine

SCHEMBL18154053

Nc1nc2nc[nH]c2c(=O)[nH]1.Nc1ncnc2nc[nH]c12.O=c1[nH]c(=O)c2[nH]cnc2[nH]1.O=c1[nH]cnc2nc[nH]c12.c1ncc2[nH]cnc2n1

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNP P00491 1/20 0.50
GDA Q9Y2T3 2/20 0.44
ACHE P22303 1/20 0.44
PI4KA P42356 2/20 0.42
PI4K2B Q8TCG2 2/20 0.42
PI4K2A Q9BTU6 2/20 0.42
PI4KB Q9UBF8 2/20 0.42
LMNA P02545 1/20 0.42
DRD3 P35462 1/20 0.42
XDH P47989 1/20 0.42
LRRK2 Q5S007 1/20 0.42
ALDH1A1 P00352 2/20 0.36
MAPT P10636 2/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
THRB P10828 1/20 0.36
HPGD P15428 1/20 0.36
KMT2A Q03164 1/20 0.36
HSD17B10 Q99714 1/20 0.36
GRIA1 P42261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanine SCHEMBL28064900 0.93 PNP (0.58) PNPGDAACHEXDHALDH1A1
Guanine SCHEMBL3820889 0.91 PNP (0.60) PNPGDAPI4KAPI4K2BPI4K2A
Guanine SCHEMBL1100665 0.84 PNP (0.70) PNPGDAXDHALDH1A1MAPT
Guanine SCHEMBL629581 0.83 PNP (0.72) PNPGDAACHEXDHALDH1A1
Xanthine SCHEMBL2784899 0.83 GDA (0.64) PNPGDAACHELMNAXDH
Xanthine SCHEMBL27773186 0.82 GDA (0.66) PNPGDAACHEPI4KAPI4K2B
Guanine SCHEMBL72148 0.81 PNP (0.77) PNPGDAACHEXDHALDH1A1
Guanine SCHEMBL1263327 0.81 PNP (0.77) PNPGDAPI4KAPI4K2BPI4K2A
Guanine SCHEMBL6307918 0.81 PNP (0.77) PNPGDAPI4KAPI4K2BPI4K2A
Guanine SCHEMBL1831281 0.81 PNP (0.77) PNPGDAPI4KAPI4K2BPI4K2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3227470-A1 CORROSION INHIBITION Services Pétroliers Schlumberger (FR) 2017-10-11 EP disclosed
WO-2016167837-A1 CORROSION INHIBITION SCHLUMBERGER CANADA LIMITED (CA) 2016-10-20 WO disclosed