Guanine

Guanine

SCHEMBL72148

Nc1nc2nc[nH]c2c(=O)[nH]1.O=c1[nH]c(=O)c2[nH]cnc2[nH]1

nearest known ligand 0.77

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNP P00491 2/20 0.77
GDA Q9Y2T3 2/20 0.68
ACHE P22303 1/20 0.68
MAPT P10636 2/20 0.50
ALDH1A1 P00352 3/20 0.49
HPGD P15428 2/20 0.49
KDM4E B2RXH2 1/20 0.49
MEN1 O00255 1/20 0.49
THRB P10828 1/20 0.49
KMT2A Q03164 1/20 0.49
HSD17B10 Q99714 1/20 0.49
USP2 O75604 1/20 0.46
TP53 P04637 1/20 0.46
ADORA3 P0DMS8 1/20 0.46
PTGS1 P23219 1/20 0.46
MAPK3 P27361 1/20 0.46
XDH P47989 1/20 0.46
HBB P68871 1/20 0.46
PAX8 Q06710 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanine SCHEMBL28135092 0.99 PNP (0.74) PNPGDAACHEMAPTALDH1A1
Guanine SCHEMBL629581 0.97 PNP (0.72) PNPGDAACHEMAPTALDH1A1
Guanine SCHEMBL28018185 0.93 PNP (0.67) PNPGDAACHEMAPTALDH1A1
Guanine SCHEMBL8090344 0.92 PNP (0.65) PNPGDAACHEMAPTALDH1A1
Guanine SCHEMBL28068968 0.91 PNP (0.63) PNPGDAACHEMAPTALDH1A1
Guanine SCHEMBL1264884 0.87 PNP (1.00) PNPGDAMAPTALDH1A1HPGD
Guanine SCHEMBL986801 0.87 PNP (1.00) PNPGDAMAPTALDH1A1HPGD
Guanine SCHEMBL5260 0.87 PNP (1.00) PNPGDAMAPTALDH1A1HPGD
Guanine SCHEMBL21611718 0.86 PNP (0.96) PNPGDAMAPTALDH1A1HPGD
Guanine SCHEMBL22533907 0.86 PNP (0.96) PNPGDAMAPTALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4841 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3856910-B1 EXPRESSION VECTORS FOR EUKARYOTIC EXPRESSION SYSTEMS MERCK SHARP & DOHME LLC (US) 2024-11-20 EP claimed
EP-3801589-B1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF OSTEOPETROSIS MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2024-08-28 EP claimed
US-11884939-B2 Vaccinia virus mutants useful for cancer immunotherapy MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2024-01-30 US claimed
EP-4297769-A2 SINGLE-CHAIN AND MULTI-CHAIN SYNTHETIC ANTIGEN RECEPTORS FOR DIVERSE IMMUNE CELLS Chaudhary, Preet, M. (US) 2024-01-03 EP claimed
CN-117202921-A Single-and multi-chain synthetic antigen receptors for a variety of immune cells 普里特·M·乔杜里 2023-12-08 CN claimed
CN-116694575-B Method for suspension culture of Marc145 cells 上海澳斯康生物制药有限公司 2023-12-01 CN claimed
CN-116694575-A Method for suspension culture of Marc145 cells 上海澳斯康生物制药有限公司 2023-09-05 CN claimed
US-20230241254-A1 IMMUNOLOGICAL DETECTION OF ALTERED CELLS ASTHRA, LLC 2023-08-03 US claimed
US-20230212319-A1 NOVEL ANTIGEN BINDING DOMAINS AND SYNTHETIC ANTIGEN RECEPTORS INCORPORATING THE SAME ANGELES THERAPEUTICS, INC. 2023-07-06 US claimed
CN-116194130-A Novel antigen binding domains and synthetic antigen receptors comprising these antigen binding domains 南加利福尼亚大学 2023-05-30 CN claimed
US-5169939-A Joining immunoglobulins and polypeptides MASSACHUSETTS INSTITUTE OF TECHNOLOGY & PRES. & FELLOWS OF HARVARD COLLEGE (US) 1992-12-08 US claimed
WO-1992007080-A1 A EUKARYOTIC EPISOMAL DNA CLONING AND EXPRESSION VECTOR BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1992-04-30 WO claimed
EP-0481790-A2 Antibody production THE WELLCOME FOUNDATION LIMITED (GB) 1992-04-22 EP claimed
EP-0443335-A1 Recombinant pox virus plasmid containing a multi-functional DNA cassette IMMUNO Aktiengesellschaft (AT) 1991-08-28 EP claimed
EP-0406436-A1 PROCESS FOR PREPARING 5'-INOSINIC ACID KYOWA HAKKO KOGYO CO., LTD. (JP) 1991-01-09 EP claimed
EP-0338807-A2 Production of isolated proteinaceous materials using recombinant avipox virus vectors IMMUNO Aktiengesellschaft (AT) 1989-10-25 EP claimed
WO-1988002022-A1 RECOMBINANT POXVIRUSES COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH OR (AU) 1988-03-24 WO claimed
EP-0183571-A2 Cosmid vectors BANYU SEIYAKU KABUSHIKI KAISHA (JP) 1986-06-04 EP claimed
EP-0073215-A1 SELECTIVE GENETIC MARKERS FOR EUCARYOTIC CELLS, METHOD FOR IMPLEMENTING SUCH MARKERS AND APPLICATION OF CELLS CONTAINING SUCH MARKER TO THE PRODUCTION OF PROTEINS DETERMINED AFTER THEIR TRANSFORMATION BY A CORRESPONDING DNA INSTITUT PASTEUR (FR) 1983-03-09 EP claimed
WO-1982003087-A1 SELECTIVE GENETIC MARKERS FOR EUCARYOTIC CELLS,METHOD FOR IMPLEMENTING SUCH MARKERS AND APPLICATION OF CELLS CONTAINING SUCH MARKER TO THE PRODUCTION OF PROTEINS DETERMINED AFTER THEIR TRANSFORMATION BY A CORRESPONDING DNA GARAPIN FLORENCE 1982-09-16 WO claimed