Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.58 |
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanine SCHEMBL18154053 | 0.93 | PNP (0.50) | PNPGDAACHEMAPTALDH1A1 | |
| Guanine SCHEMBL1100665 | 0.91 | PNP (0.70) | PNPGDAMAPTALDH1A1HPGD | |
| Xanthine SCHEMBL2784899 | 0.89 | GDA (0.64) | PNPGDAACHEALDH1A1GRIA1 | |
| Guanine SCHEMBL72148 | 0.87 | PNP (0.77) | PNPGDAACHEMAPTALDH1A1 | |
| Guanine SCHEMBL28135092 | 0.86 | PNP (0.74) | PNPGDAACHEMAPTALDH1A1 | |
| Guanine SCHEMBL27594331 | 0.85 | PNP (0.62) | PNPGDAMAPTALDH1A1HPGD | |
| Guanine SCHEMBL16552675 | 0.85 | PNP (0.62) | PNPGDAMAPTALDH1A1HPGD | |
| Guanine SCHEMBL629581 | 0.84 | PNP (0.72) | PNPGDAACHEMAPTALDH1A1 | |
| Guanine SCHEMBL3820889 | 0.84 | PNP (0.60) | PNPGDAMAPTALDH1A1HPGD | |
| Guanine SCHEMBL28068968 | 0.84 | PNP (0.63) | PNPGDAACHEMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110240654-A | In conjunction with the antibody-drug conjugates of CD73 | 复旦大学 | 2019-09-17 | — | — | CN | disclosed |
| CN-110088086-A | Disubstituted maleic amide class connexon and its preparation method and application for antibody-drug conjugate | 迈威(上海)生物科技有限公司 | 2019-08-02 | — | — | CN | disclosed |
| CN-109810039-A | Disubstituted maleimide-based linker for antibody-drug coupling, preparation method and application thereof | 上海青润医药科技有限公司 | 2019-05-28 | — | — | CN | disclosed |
| CN-105579066-B | Method for synthesizing ADC using affinity resin | ADC生物技术公司 | 2019-03-12 | — | — | CN | disclosed |
| CN-109232464-A | Oxadiazoles type connexon and its application | 上海新理念生物医药科技有限公司 | 2019-01-18 | — | — | CN | disclosed |
| CN-109219618-A | Monospecific and bispecific antibodies against epidermal growth factor receptor variants III and CD3 and uses thereof | 辉瑞大药厂 | 2019-01-15 | — | — | CN | disclosed |
| CN-108136002-A | Therapeutic antibodies and their use | 辉瑞公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-108101825-A | Disubstituted maleimide linker for antibody-drug coupling, preparation method and application thereof | 上海青润医药科技有限公司 | 2018-06-01 | — | — | CN | disclosed |
| CN-107652219-A | Four maleimide amine type connexons and its application | 上海新理念生物医药科技有限公司 | 2018-02-02 | — | — | CN | disclosed |
| CN-103933575-B | A kind of three flute profile connexons and its application | 上海新理念生物医药科技有限公司 | 2017-09-29 | — | — | CN | disclosed |
| CN-107106702-A | Method for Synthesizing ADC Using Affinity Resin | ADC生物技术公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-106267225-A | Three maleimide amine type connexon and application thereof | 上海新理念生物医药科技有限公司 | 2017-01-04 | — | — | CN | disclosed |
| CN-106279352-A | The derivant of aplysiatoxin 10 and application thereof | 上海新理念生物医药科技有限公司 | 2017-01-04 | — | — | CN | disclosed |
| CN-106211774-A | anti-CXCR 4 antibodies and antibody-drug conjugates | 辉瑞公司 | 2016-12-07 | — | — | CN | disclosed |
| CN-105579066-A | Method for Synthesizing ADC Using Affinity Resin | ADC BIOTECHNOLOGY LTD | 2016-05-11 | — | — | CN | disclosed |