Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.57 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.53 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17644774 | 0.81 | MAOB (0.68) | MAOBPARP15PARP10PARP14IDO1 | |
| SCHEMBL4380683 | 0.80 | MAOB (0.55) | MAOBIDO1SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28551904 | 0.80 | MAOB (0.69) | MAOBPARP15PARP10PARP14IDO1 | |
| SCHEMBL12423201 | 0.78 | MAOB (0.69) | MAOBPARP15PARP10PARP14IDO1 | |
| SCHEMBL3625841 | 0.77 | MAOB (0.67) | MAOBPARP15PARP10PARP14IDO1 | |
| SCHEMBL311630 | 0.75 | MAOB (0.65) | MAOBPARP15PARP10PARP14IDO1 | |
| SCHEMBL22546708 | 0.75 | MAOB (0.65) | MAOBPARP15PARP10PARP14IDO1 | |
| SCHEMBL21340831 | 0.75 | MAOB (0.65) | MAOBPARP15PARP10PARP14IDO1 | |
| SCHEMBL863430 | 0.75 | MAOB (0.60) | MAOBPARP15PARP10PARP14IDO1 | |
| SCHEMBL17804382 | 0.75 | MAOB (0.65) | MAOBPARP15PARP10PARP14IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286193-B1 | INDOLE DERIVATIVES | RICHTER GEDEON NYRT (HU) | 2020-05-27 | — | — | EP | disclosed |
| US-10329296-B2 | Indole derivatives | RICHTER GEDEON NYRT. (HU) | 2019-06-25 | — | — | US | disclosed |
| US-20180093989-A1 | INDOLE DERIVATIVES | RICHTER GEDEON NYRT. (HU) | 2018-04-05 | — | — | US | disclosed |
| EP-3286193-A1 | INDOLE DERIVATIVES | Richter Gedeon Nyrt. (HU) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016166684-A1 | INDOLE DERIVATIVES | RICHTER GEDEON NYRT. (HU) | 2016-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10329296-B2 | Indole derivatives | TPH1, MCHR1, MC1R | MAOB 67/4885PARP15 3491/4885PARP10 3530/4885 |
| US-20180093989-A1 | INDOLE DERIVATIVES | MC1R, MCHR1, TPH1 | MAOB 72/4885PARP15 3490/4885PARP10 3638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.