Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 9/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.46 |
| ▸ | GSK3B | P49841 | 5/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.45 |
| ▸ | PLK4 | O00444 | 2/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | STK17B | O94768 | 1/20 | 0.42 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 3/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30353148 | 1.00 | MEN1 (0.47) | MEN1HTTKMT2AHSD17B10AURKA | |
| SCHEMBL14771711 | 0.84 | PLK4 (0.55) | MEN1HTTKMT2AHSD17B10AURKA | |
| SCHEMBL14771709 | 0.78 | IGF1R (0.46) | AURKAAURKBGSK3BSRCPLK4 | |
| SCHEMBL18154783 | 0.78 | MEN1 (0.49) | MEN1HTTKMT2AHSD17B10AURKA | |
| SCHEMBL30353138 | 0.78 | MEN1 (0.49) | MEN1HTTKMT2AHSD17B10AURKA | |
| SCHEMBL30505027 | 0.74 | MEN1 (0.43) | MEN1HTTKMT2AHSD17B10AURKA | |
| SCHEMBL217329 | 0.74 | JAK2 (0.56) | AURKAAURKBPLK4PAK4FGFR1 | |
| SCHEMBL14771708 | 0.70 | ALDH1A1 (0.47) | KMT2AAURKAAURKBGSK3BDAPK3 | |
| SCHEMBL29537888 | 0.70 | ITK (0.62) | AURKAAURKBSRCIGF1RFGFR1 | |
| SCHEMBL588436 | 0.69 | JAK2 (0.59) | AURKBJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283482-A1 | PLK4 INHIBITORS | Ludwig Institute for Cancer Research Ltd (CH) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016166604-A1 | PLK4 INHIBITORS | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (CH) | 2016-10-20 | — | — | WO | disclosed |