Butyl Isothiocyanate

Butyl Isothiocyanate

SCHEMBL18154858

CC(C)N=C=S.CCCCN=C=S

nearest known ligand 0.59

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Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NAAA Q02083 1/20 0.59
TRPA1 O75762 11/20 0.54
TRPV1 Q8NER1 2/20 0.54
MIF P14174 5/20 0.39
KEAP1 Q14145 2/20 0.38
NFE2L2 Q16236 2/20 0.38
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
TP53 P04637 1/20 0.38
BACH1 O14867 1/20 0.38
MAFK O60675 1/20 0.38
EGFR P00533 1/20 0.38
PTGS2 P35354 1/20 0.38
GSK3B P49841 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Butyl Isothiocyanate SCHEMBL28493037 0.86 NAAA (0.53) NAAATRPA1TRPV1MIFKEAP1
Butyl Isothiocyanate SCHEMBL152568 0.84
Butyl Isothiocyanate SCHEMBL27915601 0.82
Butyl Isothiocyanate SCHEMBL28049419 0.78 NAAA (0.70) NAAATRPA1MIFKEAP1NFE2L2
1-Isothiocyanatopentane SCHEMBL175645 0.77
Butyl Isothiocyanate SCHEMBL4633771 0.76 NAAA (0.55) NAAATRPA1TRPV1MIFKEAP1
SCHEMBL1005697 0.76 NAAA (0.38) NAAATRPA1TRPV1
1-Isothiocyanatoheptane SCHEMBL330703 0.75 NAAA (1.00) NAAATRPA1MIFKEAP1NFE2L2
SCHEMBL330890 0.75 NAAA (1.00) NAAATRPA1MIFKEAP1NFE2L2
SCHEMBL1457042 0.75 NAAA (1.00) NAAATRPA1MIFKEAP1NFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3283550-A1 AMIDINE-GROUP CONTAINING CATALYST Sika Technology AG (CH) 2018-02-21 EP disclosed
WO-2016166336-A1 AMIDINE-GROUP CONTAINING CATALYST SIKA TECHNOLOGY AG (CH) 2016-10-20 WO disclosed