Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFB2 | P61812 | 1/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.47 |
| ▸ | KDR | P35968 | 6/20 | 0.47 |
| ▸ | FLT1 | P17948 | 5/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 6/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 5/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | PRKCH | P24723 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18163943 | 0.93 | TGFB2 (0.57) | TGFB2FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL18155042 | 0.86 | TGFB2 (0.64) | TGFB2FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL18164050 | 0.82 | TGFB2 (0.58) | TGFB2FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL20048367 | 0.79 | TGFB2 (0.55) | TGFB2FGFR1PDGFRBKDRPIM1 | |
| SCHEMBL18155045 | 0.78 | FGFR1 (0.54) | TGFB2FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL12833916 | 0.77 | FGFR1 (0.67) | FGFR1PDGFRBKDRFLT1PRKCB | |
| SCHEMBL14877017 | 0.74 | KDM4E (0.53) | FGFR1PDGFRBKDRFLT1MEN1 | |
| SCHEMBL14877401 | 0.74 | PDGFRB (0.57) | FGFR1PDGFRBKDRFLT1JAK3 | |
| SCHEMBL3380086 | 0.74 | FGFR1 (0.81) | FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL18155059 | 0.74 | TGFB2 (0.63) | TGFB2FGFR1PDGFRBKDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283475-B1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-10-16 | — | — | EP | claimed |
| EP-3283475-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | Merck Patent GmbH (DE) | 2018-02-21 | — | — | EP | claimed |
| WO-2016165808-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | WO | claimed |
| EP-3283475-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | Merck Patent GmbH (DE) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016165808-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | WO | disclosed |