Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18155244 | 0.92 | HSD17B10 (0.38) | KDM4EHSD17B10MAPTALDH1A1LMNA | |
| SCHEMBL18155278 | 0.88 | KDM4E (0.35) | KDM4EHSD17B10MAPTALDH1A1LMNA | |
| SCHEMBL13653937 | 0.88 | HTR6 (0.38) | KDM4EHSD17B10MAPTALDH1A1LMNA | |
| SCHEMBL1120623 | 0.88 | KDM4E (0.36) | KDM4EHSD17B10MAPTALDH1A1LMNA | |
| SCHEMBL18155259 | 0.87 | KDM4E (0.36) | KDM4EHSD17B10MAPTALDH1A1LMNA | |
| SCHEMBL18155270 | 0.86 | HTR6 (0.40) | KDM4EHSD17B10MAPTALDH1A1LMNA | |
| SCHEMBL18155247 | 0.86 | HRH1 (0.38) | KDM4EHSD17B10MAPTALDH1A1LMNA | |
| SCHEMBL18155293 | 0.85 | KDM4E (0.33) | KDM4EHSD17B10MAPTALDH1A1LMNA | |
| SCHEMBL18155263 | 0.83 | HRH1 (0.40) | KDM4EHSD17B10MAPTALDH1A1LMNA | |
| SCHEMBL13654454 | 0.81 | KDM4E (0.39) | KDM4EHSD17B10MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9469641-B2 | Pyrido[3,4-B]indoles and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2016-10-18 | — | — | US | disclosed |