Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.40 |
| ▸ | HTR6 | P50406 | 5/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13663439 | 0.91 | CYP11B1 (0.36) | DRD2DRD3DRD4KDM4EGRM5 | |
| SCHEMBL18155247 | 0.89 | HRH1 (0.38) | HRH1HTR6KDM4EHSD17B10MAPT | |
| SCHEMBL18155267 | 0.89 | HRH1 (0.39) | HRH1HTR6DRD2DRD3DRD4 | |
| SCHEMBL18155244 | 0.87 | HSD17B10 (0.38) | HRH1HTR6KDM4EHSD17B10MAPT | |
| SCHEMBL13653937 | 0.83 | HTR6 (0.38) | HRH1HTR6KDM4EHSD17B10MAPT | |
| SCHEMBL18155253 | 0.83 | KDM4E (0.38) | KDM4EHSD17B10MAPTALDH1A1LMNA | |
| SCHEMBL1120623 | 0.83 | KDM4E (0.36) | HTR6KDM4EHSD17B10MAPTALDH1A1 | |
| SCHEMBL18155270 | 0.82 | HTR6 (0.40) | HRH1HTR6DRD2DRD4KDM4E | |
| SCHEMBL18155278 | 0.82 | KDM4E (0.35) | HRH1HTR6KDM4EHSD17B10MAPT | |
| SCHEMBL13654435 | 0.80 | KDM4E (0.37) | KDM4EHSD17B10MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9469641-B2 | Pyrido[3,4-B]indoles and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2016-10-18 | — | — | US | disclosed |