Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13663451 | 0.91 | HTR2A (0.34) | MAPTMAOAKDM4ECYP3A4CYP2D6 | |
| SCHEMBL18155277 | 0.90 | HSD17B10 (0.33) | MAPTMAOAHSD17B10KDM4EMEN1 | |
| SCHEMBL18155293 | 0.88 | KDM4E (0.33) | MAPTTHRBMAOAHSD17B10KDM4E | |
| SCHEMBL18155286 | 0.86 | HTR6 (0.40) | MAOAHSD17B10KDM4EMEN1TP53 | |
| SCHEMBL13663461 | 0.86 | HTR6 (0.38) | MAPTMAOAHSD17B10KDM4EMEN1 | |
| SCHEMBL18155246 | 0.86 | HSD17B10 (0.37) | MAPTMAOAHSD17B10KDM4EMEN1 | |
| SCHEMBL18155259 | 0.84 | KDM4E (0.36) | MAPTMAOAHSD17B10KDM4EMEN1 | |
| SCHEMBL1120646 | 0.82 | KDM4E (0.34) | MAPTMAOAHSD17B10KDM4EMEN1 | |
| SCHEMBL3240243 | 0.82 | HTR6 (0.39) | ADRA2ADRD1HRH1HTR6 | |
| SCHEMBL13654591 | 0.81 | KDM4E (0.34) | MAPTKDM4EDRD1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9469641-B2 | Pyrido[3,4-B]indoles and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2016-10-18 | — | — | US | disclosed |