SCHEMBL18155901

SCHEMBL18155901

CC(=O)c1c(C)cc(C)c(C(=O)c2ccccc2)c1C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.47
HTT P42858 2/20 0.47
ALDH1A1 P00352 7/20 0.46
L3MBTL1 Q9Y468 2/20 0.45
ATM Q13315 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
MAPT P10636 3/20 0.45
BCL2L1 Q07817 1/20 0.43
CES2 O00748 2/20 0.42
CES1 P23141 2/20 0.42
ELANE P08246 1/20 0.42
GRM6 O15303 1/20 0.41
MEN1 O00255 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
KMT2A Q03164 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
SRD5A2 P31213 1/20 0.41
PLA2G1B P04054 1/20 0.41
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15552435 0.87 AKR1C3 (0.48) LMNAHTTALDH1A1L3MBTL1ATM
SCHEMBL29378123 0.87 AKR1C3 (0.48) LMNAHTTALDH1A1L3MBTL1ATM
SCHEMBL16926375 0.84 ALDH1A1 (0.45) LMNAHTTALDH1A1L3MBTL1ATM
SCHEMBL2810235 0.82 CYP3A4 (0.44) LMNAALDH1A1MAPTMEN1NPC1
SCHEMBL98045 0.80 ALDH1A1 (0.45) LMNAHTTALDH1A1L3MBTL1ATM
SCHEMBL243118 0.80 ALDH1A1 (0.51) LMNAHTTALDH1A1L3MBTL1ATM
SCHEMBL8067279 0.80 ALDH1A1 (0.45) LMNAHTTALDH1A1L3MBTL1ATM
SCHEMBL18142835 0.80 ALDH1A1 (0.41) LMNAHTTALDH1A1L3MBTL1ATM
SCHEMBL11484517 0.79 BCL2L1 (0.51) LMNAHTTALDH1A1L3MBTL1ATM
SCHEMBL4419668 0.79 MAPT (0.49) LMNAHTTALDH1A1L3MBTL1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2877500-B1 PHOTOPOLYMERISATION PROCESSES AND NOVEL COMPOUNDS THEREFOR LAMBSON LTD (GB) 2016-10-19 EP disclosed