Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12362559 | 0.87 | CYP2C9 (0.41) | PPARGPGRALDH1A1AGTR1KDM4E | |
| SCHEMBL6451041 | 0.75 | AGTR1 (0.46) | PPARGALDH1A1AGTR1KDM4EABCC3 | |
| SCHEMBL6448038 | 0.75 | AGTR1 (0.50) | PPARGALDH1A1AGTR1KDM4EABCC3 | |
| SCHEMBL7043121 | 0.74 | AGTR1 (0.49) | PPARGALDH1A1AGTR1KDM4EABCC3 | |
| SCHEMBL12362562 | 0.73 | PPARG (0.41) | PPARGALDH1A1AGTR1KDM4EABCC3 | |
| SCHEMBL12362496 | 0.72 | PPARG (0.45) | PPARGALDH1A1AGTR1KDM4EABCC3 | |
| SCHEMBL6458741 | 0.70 | CYP2C9 (0.49) | PPARGALDH1A1AGTR1KDM4EABCC3 | |
| SCHEMBL6453074 | 0.69 | AGTR1 (0.43) | PPARGALDH1A1AGTR1KDM4EABCC3 | |
| SCHEMBL12362556 | 0.68 | PPARG (0.46) | PPARGALDH1A1AGTR1KDM4EABCC3 | |
| SCHEMBL2126020 | 0.67 | PPARG (0.53) | PPARGALDH1A1AGTR1KDM4EABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3081213-A1 | TRICYCLIC COMPOUND | Kyowa Hakko Kirin Co., Ltd. (JP) | 2016-10-19 | — | — | EP | disclosed |