Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 6/20 | 0.60 |
| ▸ | CDC25B | P30305 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | SAE1 | Q9UBE0 | 4/20 | 0.50 |
| ▸ | UBA2 | Q9UBT2 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | UBE2I | P63279 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 3/20 | 0.48 |
| ▸ | APAF1 | O14727 | 3/20 | 0.48 |
| ▸ | CASP3 | P42574 | 3/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30161077 | 0.83 | TNKS (0.65) | TNKSCDC25BKDM4ESAE1UBA2 | |
| SCHEMBL28924699 | 0.83 | TNKS (0.65) | TNKSCDC25BKDM4ESAE1UBA2 | |
| SCHEMBL828493 | 0.82 | TNKS (0.63) | TNKSCDC25BKDM4ESAE1UBA2 | |
| SCHEMBL29639160 | 0.82 | TNKS (0.63) | TNKSCDC25BKDM4ESAE1UBA2 | |
| SCHEMBL311943 | 0.80 | TNKS (0.61) | TNKSCDC25BKDM4ESAE1UBA2 | |
| SCHEMBL28624953 | 0.80 | PARP1 (0.61) | TNKSCDC25BKDM4ESAE1UBA2 | |
| SCHEMBL28629565 | 0.80 | TNKS (0.61) | TNKSCDC25BKDM4ESAE1UBA2 | |
| SCHEMBL4774571 | 0.80 | TNKS (0.61) | TNKSCDC25BKDM4ESAE1UBA2 | |
| SCHEMBL30160913 | 0.80 | PARP1 (0.61) | TNKSCDC25BKDM4ESAE1UBA2 | |
| SCHEMBL16578791 | 0.80 | TNKS (0.61) | TNKSCDC25BKDM4ESAE1UBA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822656-B1 | 3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE | CANCER RES INST ROYAL (GB) | 2016-10-19 | — | — | EP | disclosed |