Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 6/20 | 0.63 |
| ▸ | PARP1 | P09874 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.53 |
| ▸ | CTSV | O60911 | 1/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | TUBB | P07437 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.53 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.53 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.53 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL828493 | 1.00 | TNKS (0.63) | TNKSPARP1KDM4EHPGDALDH1A1 | |
| SCHEMBL30161077 | 0.86 | TNKS (0.65) | TNKSPARP1KDM4EHPGDALDH1A1 | |
| SCHEMBL4774571 | 0.86 | TNKS (0.61) | TNKSPARP1KDM4EHPGDALDH1A1 | |
| SCHEMBL28629565 | 0.86 | TNKS (0.61) | TNKSPARP1KDM4EHPGDALDH1A1 | |
| SCHEMBL311943 | 0.86 | TNKS (0.61) | TNKSPARP1KDM4EHPGDALDH1A1 | |
| SCHEMBL30160913 | 0.86 | PARP1 (0.61) | TNKSPARP1KDM4EHPGDALDH1A1 | |
| SCHEMBL28924699 | 0.86 | TNKS (0.65) | TNKSPARP1KDM4EHPGDALDH1A1 | |
| SCHEMBL28624953 | 0.86 | PARP1 (0.61) | TNKSPARP1KDM4EHPGDALDH1A1 | |
| SCHEMBL22201443 | 0.86 | ALDH1A1 (0.59) | TNKSPARP1KDM4EHPGDALDH1A1 | |
| SCHEMBL16578791 | 0.86 | TNKS (0.61) | TNKSPARP1KDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113666925-B | Method for synthesizing isoindolo [2,1-b ] isoquinoline-5 (7H) -ketone compound | 广州大学 | 2022-05-17 | — | — | CN | claimed |
| EP-4709711-A1 | ISOQUINOLINONE DERIVATIVES AND 4H-QUINOLIZINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF DISEASE | Beone Medicines I GmbH (CH) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024230803-A1 | ISOQUINOLINONE DERIVATIVES AND 4H-QUINOLIZINONE DERIVATIVES AND PHARMARCEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF DISEASE | BEIGENE, LTD. (GB) | 2024-11-14 | — | — | WO | disclosed |
| CN-115521310-A | Synthesis method of isoindole isoquinoline spironaphthone compound | 河南师范大学 | 2022-12-27 | — | — | CN | disclosed |
| CN-113666925-B | Method for synthesizing isoindolo [2,1-b ] isoquinoline-5 (7H) -ketone compound | 广州大学 | 2022-05-17 | — | — | CN | disclosed |