Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.34 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22423114 | 1.00 | MAPT (0.36) | MAPTALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL19008441 | 0.98 | MAPT (0.35) | MAPTALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL20224303 | 0.97 | MAPT (0.34) | MAPTALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL17117663 | 0.97 | ALOX5 (0.36) | MAPTALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL16855636 | 0.97 | ALOX5 (0.36) | MAPTALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL18732069 | 0.96 | ALOX5 (0.35) | MAPTALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL20224307 | 0.96 | ALOX5 (0.35) | MAPTALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL18156717 | 0.96 | ALOX5 (0.36) | MAPTALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL18156835 | 0.96 | ALOX5 (0.36) | MAPTALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL16855610 | 0.96 | ALOX5 (0.36) | MAPTALDH1A1KMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11545634-B2 | Heterocyclic spiro compounds | MERCK PATENT GMBH (DE) | 2023-01-03 | — | — | US | disclosed |
| EP-3708634-A1 | HETEROCYCLIC SPIRO COMPOUNDS | Merck Patent GmbH (DE) | 2020-09-16 | — | — | EP | disclosed |
| US-10777750-B2 | Heterocyclic spiro compounds | BASF SE (DE) | 2020-09-15 | — | — | US | disclosed |
| EP-3083880-B1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2020-04-01 | — | — | EP | disclosed |
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | MAPT 3089/4885ALDH1A1 383/4885KMT2A 3328/4885 |
| US-11545634-B2 | Heterocyclic spiro compounds | NES, KCNC1, HCN4 | MAPT 3089/4885ALDH1A1 383/4885KMT2A 3328/4885 |
| US-10777750-B2 | Heterocyclic spiro compounds | NES, KCNC1, HCN4 | MAPT 3089/4885ALDH1A1 383/4885KMT2A 3328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.