KCNC1

Voltage-gated potassium channel KCNC1 · P48547 · KCNC1 on Sugi Atlas →

28 patent compounds predicted against KCNC1, 22 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Bergapten (SCHEMBL50066)	0.63	1/20
Bergapten (SCHEMBL4731782)	0.63	1/20
Bergapten (SCHEMBL29529284)	0.63	1/20
Isopimpinellin (SCHEMBL29787210)	0.54	1/20
SCHEMBL3975535	0.53	1/20
Bergapten (SCHEMBL15534211)	0.52	1/20
Visnagin (SCHEMBL498450)	0.51	1/20
Visnagin (SCHEMBL31670263)	0.51	1/20
Bergapten (SCHEMBL9792363)	0.50	1/20
SCHEMBL10922801	0.50	1/20
SCHEMBL1663878	0.48	1/20
SCHEMBL29405339	0.48	1/20
SCHEMBL30105577	0.47	1/20
SCHEMBL9129946	0.47	1/20
SCHEMBL31547906	0.44	1/20
SCHEMBL4795310	0.44	1/20
SCHEMBL8440887	0.44	1/20
SCHEMBL20589928	0.42	1/20
SCHEMBL9157270	0.42	1/20
SCHEMBL9164017	0.41	1/20

Clinical trials — most relevant to KCNC1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery	PHASE4	RECRUITING
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy	PHASE1/PHASE2	RECRUITING
Mutation-specific Therapy for the Long QT Syndrome	PHASE2	COMPLETED
Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients	PHASE2	COMPLETED
Sandostatine® LP and Hyperinsulinism	PHASE2	COMPLETED
N-of-1 in ATS and MEPPC	PHASE2	NOT_YET_RECRUITING
Safety, Blood Levels and Effects of AUT00201 in Patients With MEAK	PHASE1	COMPLETED
A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours	PHASE1	COMPLETED
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.	nan	UNKNOWN
Qatar Cardiovascular Biorepository of AF Patients	nan	UNKNOWN
The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism	nan	COMPLETED
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
The Effects of the Anesthetic Drug Propofol on the Way the Heart Recovers Between Beats	nan	COMPLETED
Genetic Determinants of Sudden Cardiac Death	nan	COMPLETED
The Effects of the Anti Nausea Drugs Droperidol and Ondansetron on the Way the Heart Recovers Between Beats	nan	COMPLETED
Characteristics of Episodic Ataxia Syndrome	nan	COMPLETED
Interaction of Potassium and Genetic Risk Variants on Diabetes Risk	nan	COMPLETED
Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA)	nan	UNKNOWN
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.	nan	UNKNOWN
Metabolism of Patients With Genetically Caused Cardiac Arrhythmia	nan	UNKNOWN
Relationship Between Polymorphisms of TRPV1 and KCC2 Gene in Children With Febrile Seizures	nan	COMPLETED
Mayo AVC Registry and Biobank	nan	RECRUITING
A Cohort Study on the Prognosis of Neonatal KCNQ2 Gene-associated Epileptic Encephalopathy	nan	UNKNOWN
Characteristics of Andersen-Tawil Syndrome	nan	COMPLETED
Development of an Artificial Intelligence Algorithm to Detect Pathological Repolarization Disorders on the ECG and the Risk of Ventricular Arrhythmias	nan	RECRUITING
Clinical-genetic Investigations in Children With Early Infantile Epilepsies	nan	COMPLETED
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services	nan	UNKNOWN
The Genetic Basis of Atrial Fibrillation (AF)	nan	COMPLETED
Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases	nan	UNKNOWN
A Positional Cloning Study on Schizophrenia	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a KCNC1 binder may also engage these)

Protein	Name	Similarity
P15388	—	1.000	P15388 →
P25122	—	1.000	P25122 →
Q63734	—	0.994	Q63734 →
Q03721	—	0.992	Q03721 →
KCNA2	Potassium voltage-gated channel subfamily A member 2	0.992	landscape →
Q14B80	—	0.991	Q14B80 →
P16390	—	0.991	P16390 →
KCNA1	Potassium voltage-gated channel subfamily A member 1	0.989	landscape →
P22739	—	0.989	P22739 →
Q96PR1	—	0.989	Q96PR1 →
Q8BZN2	—	0.989	Q8BZN2 →
P17972	—	0.988	P17972 →
P22462	—	0.988	P22462 →
Q52PG9	—	0.988	Q52PG9 →
Q9ULS6	—	0.988	Q9ULS6 →
Q28293	—	0.988	Q28293 →
KCNA6	Potassium voltage-gated channel subfamily A member 6	0.988	landscape →
P15384	—	0.987	P15384 →
Q03719	—	0.987	Q03719 →
Q9H3M0	—	0.987	Q9H3M0 →
P63141	—	0.987	P63141 →
P17659	—	0.987	P17659 →
P63142	—	0.987	P63142 →
A4K2P6	—	0.987	A4K2P6 →
A4K2M4	—	0.987	A4K2M4 →
G5EFC3	—	0.987	G5EFC3 →
P59053	—	0.986	P59053 →
Q9TT17	—	0.986	Q9TT17 →
Q8TAE7	—	0.986	Q8TAE7 →
Q8TDN2	—	0.986	Q8TDN2 →