Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18156825 | 0.96 | ALOX5 (0.35) | ALOX5ESR1ESR2DYRK1AGGPS1 | |
| SCHEMBL22617619 | 0.80 | ALOX5 (0.42) | ALOX5GGPS1 | |
| SCHEMBL22617615 | 0.80 | AHR (0.43) | ALOX5 | |
| SCHEMBL18156826 | 0.79 | ESR1 (0.34) | ALOX5ESR1ESR2 | |
| SCHEMBL16855453 | 0.79 | ESR1 (0.31) | ESR1ESR2 | |
| SCHEMBL22617620 | 0.78 | ALOX5 (0.43) | ALOX5GGPS1 | |
| SCHEMBL18156822 | 0.78 | ALOX5 (0.33) | ALOX5ESR1ESR2 | |
| SCHEMBL16855373 | 0.78 | ESR1 (0.32) | ESR1ESR2 | |
| SCHEMBL22617653 | 0.77 | ALOX5 (0.37) | ALOX5GGPS1 | |
| SCHEMBL22617715 | 0.77 | ALOX5 (0.45) | ALOX5DYRK1AGGPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2023-04-27 | — | — | US | disclosed |
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2023-04-27 | — | — | US | disclosed |
| US-11545634-B2 | Heterocyclic spiro compounds | MERCK PATENT GMBH (DE) | 2023-01-03 | — | — | US | disclosed |
| EP-3708634-A1 | HETEROCYCLIC SPIRO COMPOUNDS | Merck Patent GmbH (DE) | 2020-09-16 | — | — | EP | disclosed |
| US-10777750-B2 | Heterocyclic spiro compounds | BASF SE (DE) | 2020-09-15 | — | — | US | disclosed |
| US-20200266364-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2020-08-20 | — | — | US | disclosed |
| EP-3083880-B1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2020-04-01 | — | — | EP | disclosed |
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | ALOX5 3721/4885ESR1 107/4885ESR2 130/4885 |
| US-11545634-B2 | Heterocyclic spiro compounds | NES, KCNC1, HCN4 | ALOX5 3721/4885ESR1 107/4885ESR2 130/4885 |
| US-20200266364-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | ALOX5 3721/4885ESR1 107/4885ESR2 130/4885 |
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | ALOX5 3721/4885ESR1 107/4885ESR2 130/4885 |
| US-10777750-B2 | Heterocyclic spiro compounds | NES, KCNC1, HCN4 | ALOX5 3721/4885ESR1 107/4885ESR2 130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.