SCHEMBL18159136

SCHEMBL18159136

C#CCNC(=O)[C@H](N)CCCNC(=N)N

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
DPP7 Q9UHL4 2/20 0.47
GNAI3 P08754 1/20 0.42
GNAO1 P09471 1/20 0.42
GNAI1 P63096 1/20 0.42
RRM1 P23921 1/20 0.41
NPY4R P50391 8/20 0.40
NPY1R P25929 5/20 0.40
NPY2R P49146 4/20 0.40
NPY5R Q15761 4/20 0.40
OTC P00480 1/20 0.37
NOD1 Q9Y239 1/20 0.36
NOS1 P29475 2/20 0.36
NOS3 P29474 1/20 0.36
NOS2 P35228 1/20 0.36
DDAH1 O94760 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13881429 0.88 NPY4R (0.51) DPP7NPY4RNPY1RNPY2RNPY5R
SCHEMBL6368164 0.86 DPP7 (0.49) DPP7GNAI3GNAO1GNAI1RRM1
SCHEMBL6368171 0.86 DPP7 (0.49) DPP7GNAI3GNAO1GNAI1RRM1
SCHEMBL1521349 0.86 DPP7 (0.49) DPP7GNAI3GNAO1GNAI1RRM1
SCHEMBL23626315 0.84 DPP7 (0.61) DPP7GNAI3GNAO1GNAI1RRM1
SCHEMBL23610947 0.84 DPP7 (0.61) DPP7GNAI3GNAO1GNAI1RRM1
SCHEMBL2304732 0.83 DPP7 (0.56) DPP7GNAI3GNAO1GNAI1RRM1
SCHEMBL13062154 0.83 DPP7 (0.56) DPP7GNAI3GNAO1GNAI1RRM1
SCHEMBL25677222 0.82 CACNA1B (0.36) NPY4RNPY1RNPY2RNPY5R
SCHEMBL19371883 0.81 DPP7 (0.63) DPP7GNAI3GNAO1GNAI1RRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230165964-A1 Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same DURECT CORP (US) 2023-06-01 US disclosed
US-20230165964-A1 Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same DURECT CORP (US) 2023-06-01 US disclosed
US-11529420-B2 Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same DURECT CORPORATION (US) 2022-12-20 US disclosed
US-20210038731-A1 Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same DURECT CORPORATION (US) 2021-02-11 US disclosed
US-10758623-B2 Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same DURECT CORPORATION (US) 2020-09-01 US disclosed
US-20160303242-A1 Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same DURECT CORPORATION (US) 2016-10-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230165964-A1 Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same PAICS, PARG, PUF60 DPP7 2424/4885GNAI3 2350/4885GNAO1 3111/4885
US-11529420-B2 Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same PAICS, PARG, PUF60 DPP7 2424/4885GNAI3 2350/4885GNAO1 3111/4885
US-20160303242-A1 Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same PAICS, PARG, PUF60 DPP7 2424/4885GNAI3 2350/4885GNAO1 3111/4885
US-20210038731-A1 Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same PAICS, PARG, PUF60 DPP7 2424/4885GNAI3 2350/4885GNAO1 3111/4885
US-10758623-B2 Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same PAICS, PARG, PUF60 DPP7 2424/4885GNAI3 2350/4885GNAO1 3111/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.