Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 2/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.30 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.30 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16800967 | 0.88 | ALDH1A1 (0.38) | S1PR4S1PR5ALOX5ABCG2ALDH1A1 | |
| SCHEMBL18159552 | 0.87 | HPGD (0.39) | ALOX5CASP3SENP7SENP6ABCG2 | |
| SCHEMBL16801512 | 0.84 | MAPT (0.44) | ALOX5CASP3SENP7SENP6ALDH1A1 | |
| SCHEMBL16801060 | 0.84 | ALDH1A1 (0.36) | ALOX5ABCG2ALDH1A1CYP1A2THRB | |
| SCHEMBL24363018 | 0.84 | CYP1A2 (0.36) | S1PR4S1PR5ALOX5CASP3SENP7 | |
| SCHEMBL16801277 | 0.83 | ALDH1A1 (0.39) | ABCG2ALDH1A1CYP1A2THRBHPGD | |
| SCHEMBL16801450 | 0.82 | ALDH1A1 (0.38) | ABCG2ALDH1A1CYP1A2THRBHPGD | |
| SCHEMBL18159548 | 0.82 | ALDH1A1 (0.38) | ABCG2ALDH1A1CYP1A2THRBHPGD | |
| SCHEMBL16801456 | 0.81 | GSTP1 (0.42) | ALOX5ABCG2ALDH1A1CYP1A2THRB | |
| SCHEMBL24363013 | 0.81 | AHR (0.33) | ALOX5ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11917913-B2 | Substituted oxepines | MERCK PATENT GMBH (DE) | 2024-02-27 | — | — | US | disclosed |
| US-11917913-B2 | Substituted oxepines | MERCK PATENT GMBH (DE) | 2024-02-27 | — | — | US | disclosed |
| US-20190280218-A1 | SUBSTITUTED OXEPINES | MERCK PATENT GMBH (DE) | 2019-09-12 | — | — | US | disclosed |
| US-10374170-B2 | Substituted oxepines | MERCK PATENT GMBH (DE) | 2019-08-06 | — | — | US | disclosed |
| US-20160308146-A1 | SUBSTITUTED OXEPINES | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
| US-20160308146-A1 | SUBSTITUTED OXEPINES | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11917913-B2 | Substituted oxepines | OXGR1, OXTR, OCIAD2 | S1PR4 3941/4885S1PR5 4201/4885ALOX5 1897/4885 |
| US-10374170-B2 | Substituted oxepines | OXGR1, OXTR, OCIAD2 | S1PR4 3941/4885S1PR5 4201/4885ALOX5 1897/4885 |
| US-20190280218-A1 | SUBSTITUTED OXEPINES | OXGR1, OXTR, OCIAD2 | S1PR4 3941/4885S1PR5 4201/4885ALOX5 1897/4885 |
| US-20160308146-A1 | SUBSTITUTED OXEPINES | OXGR1, OXTR, OCIAD2 | S1PR4 3941/4885S1PR5 4201/4885ALOX5 1897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.