Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.36 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 5/20 | 0.35 |
| ▸ | BPTF | Q12830 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20897979 | 0.77 | BTK (0.43) | BTKCYP2C9GAAPARP1 | |
| SCHEMBL28292785 | 0.73 | BTK (0.41) | BTKCYP2C9GAAPARP1 | |
| SCHEMBL1710509 | 0.72 | ROCK1 (0.34) | BTKOPRM1OPRD1OPRK1 | |
| SCHEMBL20971823 | 0.70 | GPR119 (0.52) | — | |
| SCHEMBL16042892 | 0.70 | CA1 (0.47) | BPTFHDAC6PARP1 | |
| SCHEMBL3783315 | 0.68 | PARP1 (0.43) | PARP10BPTFHDAC6PARP1 | |
| SCHEMBL1233573 | 0.68 | HDAC1 (0.44) | BPTFHDAC6PARP1 | |
| SCHEMBL5722433 | 0.67 | L3MBTL1 (0.33) | BTK | |
| SCHEMBL811633 | 0.66 | PARP1 (0.45) | PARP10HDAC6PARP1 | |
| SCHEMBL27630458 | 0.66 | ERN1 (0.39) | PARP10BPTFHDAC6KCNH2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498775-A1 | NEW 7-PHENYL-[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3(2H)-ONE DERIVATIVES | Almirall S.A. (ES) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011057757-A1 | NEW 7-PHENYL-[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3(2H)-ONE DERIVATIVES | ALMIRALL, S.A. (ES) | 2011-05-19 | — | — | WO | disclosed |