Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMX | P51813 | 13/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.49 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18164360 | 0.80 | RXFP1 (0.53) | BMXMAPK14DDR1BTKABL1 | |
| SCHEMBL13498137 | 0.76 | EGFR (0.53) | BTKRXFP1POLBTHRBAHR | |
| SCHEMBL14026833 | 0.76 | BRAF (0.42) | RXFP1POLBTHRBMEN1KMT2A | |
| SCHEMBL4788880 | 0.75 | BTK (0.43) | MAPK14BTK | |
| SCHEMBL24393253 | 0.74 | SYK (0.46) | RXFP1AHRMEN1KMT2A | |
| SCHEMBL29537649 | 0.74 | SYK (0.46) | RXFP1AHRMEN1KMT2A | |
| SCHEMBL20865561 | 0.74 | ALDH1A1 (0.56) | RXFP1POLBMEN1KMT2A | |
| SCHEMBL15992951 | 0.74 | MAPK1 (0.58) | POLBMEN1KMT2A | |
| SCHEMBL31173043 | 0.73 | CA12 (0.52) | MEN1KMT2A | |
| SCHEMBL13498135 | 0.73 | SYK (0.55) | BTKMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016165205-A1 | NOVEL BCR-ABL KINASE INHIBITOR | 中国科学院合肥物质科学研究院 | 2016-10-20 | — | — | WO | disclosed |