Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | ELANE | P08246 | 4/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | BCL2 | P10415 | 3/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16430969 | 0.83 | BCL2 (0.54) | LCKELANEMAOAMAOBBCL2 | |
| SCHEMBL10797765 | 0.77 | MAPT (0.53) | LCKMAOAMAOBBCL2MCL1 | |
| SCHEMBL1819208 | 0.77 | LCK (0.46) | LCKELANEALDH1A1MAPTMEN1 | |
| SCHEMBL5968251 | 0.75 | BCL2 (0.67) | LCKELANEMAOAMAOBBCL2 | |
| SCHEMBL7172505 | 0.72 | LCK (1.00) | LCKELANEMAOAMAOBBCL2 | |
| SCHEMBL16932394 | 0.72 | ELANE (0.55) | LCKELANEMAOAMAOBBCL2 | |
| SCHEMBL30961641 | 0.72 | ELANE (0.55) | LCKELANEMAOAMAOBBCL2 | |
| SCHEMBL182959 | 0.72 | ELANE (0.86) | LCKELANEMAOAMAOBBCL2 | |
| SCHEMBL2610165 | 0.72 | ELANE (0.77) | LCKELANEMAOAMAOBBCL2 | |
| SCHEMBL583153 | 0.72 | ELANE (0.86) | LCKELANEMAOAMAOBBCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023140186-A1 | PHOTOCHROMIC COMPOUND, NAPHTHOL DERIVATIVE, CURABLE COMPOSITION, OPTICAL ARTICLE, LENS, AND EYEGLASSES | 株式会社トクヤマ | 2023-07-27 | — | — | WO | disclosed |
| WO-2023136213-A1 | PHOTOCHROMIC COMPOUND, NAPHTHOL DERIVATIVE, CURABLE COMPOSITION, OPTICAL ARTICLE, LENS, AND EYEGLASSES | 株式会社トクヤマ | 2023-07-20 | — | — | WO | disclosed |
| EP-2494408-B9 | PHOTOCHROMIC MATERIALS | TRANSITIONS OPTICAL INC (US) | 2015-09-02 | — | — | EP | disclosed |
| EP-2494408-B1 | PHOTOCHROMIC MATERIALS | TRANSITIONS OPTICAL INC (US) | 2015-04-15 | — | — | EP | disclosed |
| US-8518305-B2 | Photochromic materials | TRANSITIONS OPTICAL, INC. (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2494408-A1 | PHOTOCHROMIC MATERIALS | Transitions Optical, Inc. (US) | 2012-09-05 | — | — | EP | disclosed |
| US-20110108781-A1 | PHOTOCHROMIC MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2011-05-12 | — | — | US | disclosed |
| WO-2011053615-A1 | PHOTOCHROMIC MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2011-05-05 | — | — | WO | disclosed |
| EP-1465963-B1 | PHOTOCHROMIC POLYMER COMPOSITIONS AND ARTICLES THEREOF | TRANSITIONS OPTICAL INC (US) | 2010-03-03 | — | — | EP | disclosed |
| US-20070001155-A1 | Photochromic polymer compositions and articles thereof | WALTERS ROBERT W | 2007-01-04 | — | — | US | disclosed |
| US-6555028-B2 | Polymeric matrix compatibilized naphthopyrans | TRANSITIONS OPTICAL, INC. | 2003-04-29 | — | — | US | disclosed |
| EP-1208392-A1 | PROCESS FOR THE MANUFACTURE OF A CROSSLINKED, TRANSPARENT, HYDROPHILIC AND PHOTOCHROMIC POLYMERIC MATERIAL, AND OPTICAL AND OPHTHALMIC ARTICLE OBTAINED | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2002-05-29 | — | — | EP | disclosed |
| EP-0792468-B1 | NOVEL PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS | PPG IND OHIO INC (US) | 2002-04-03 | — | — | EP | disclosed |
| US-20010025948-A1 | Polymeric matrix compatibilized naphthopyrans | TRANSITIONS OPTICAL LIMITED (IE) | 2001-10-04 | — | — | US | disclosed |
| WO-2001009645-A1 | PROCESS FOR THE MANUFACTURE OF A CROSSLINKED, TRANSPARENT, HYDROPHILIC AND PHOTOCHROMIC POLYMERIC MATERIAL, AND OPTICAL AND OPHTHALMIC ARTICLE OBTAINED | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2001-02-08 | — | — | WO | disclosed |
| US-6113814-A | PHOTOCHROMIC; END-CAPPED WITH A POLYMERIZABLE GROUP. | TRANSITIONS OPTICAL, INC. (US) | 2000-09-05 | — | — | US | disclosed |
| EP-0792468-A4 | NOVEL PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS | PPG INDUSTRIES INC (US) | 1999-03-03 | — | — | EP | disclosed |
| EP-0792468-A1 | NOVEL PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS | PPG INDUSTRIES, INC. (US) | 1997-09-03 | — | — | EP | disclosed |
| US-5645767-A | PLASTIC LENSES, WINDOWS, BATHOCHROMIC SHIFT FOR WAVELENGTHS IN VISIBLE SPECTRUM | TRANSITIONS OPTICAL, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| WO-1996014596-A1 | NOVEL PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRANS | PPG INDUSTRIES, INC. (US) | 1996-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110108781-A1 | PHOTOCHROMIC MATERIALS | INCENP, SMCHD1, NEDD8 | LCK 3459/4885ELANE 2054/4885MAOA 2242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.