NEDD8

Ubiquitin-like protein NEDD8 · Q15843 · NEDD8 on Sugi Atlas →

1,386 patent compounds predicted against NEDD8, 1,108 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Micafungin (SCHEMBL37671)	1.00	1/20
Pevonedistat (SCHEMBL192291)	1.00	1/20
Pevonedistat (SCHEMBL192875)	1.00	1/20
Micafungin (SCHEMBL1652133)	1.00	1/20
Pevonedistat (SCHEMBL1800436)	1.00	1/20
Pevonedistat (SCHEMBL10016613)	1.00	1/20
Pevonedistat (SCHEMBL10048256)	1.00	1/20
Micafungin (SCHEMBL11893279)	1.00	1/20
Micafungin (SCHEMBL13575751)	1.00	1/20
Micafungin (SCHEMBL14071559)	1.00	1/20
Pevonedistat (SCHEMBL14321349)	1.00	1/20
Pevonedistat (SCHEMBL14328898)	1.00	1/20
Micafungin (SCHEMBL14380016)	1.00	1/20
Micafungin (SCHEMBL14403608)	1.00	1/20
Pevonedistat (SCHEMBL15685348)	1.00	1/20
Pevonedistat (SCHEMBL936080)	0.98	1/20
SCHEMBL13660132	0.92	1/20
SCHEMBL193662	0.91	1/20
SCHEMBL14218464	0.91	1/20
SCHEMBL14539491	0.90	1/20

Clinical trials — most relevant to NEDD8 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Study to Evaluate the Safety, Immunogenicity, and Efficacy of UB-612 COVID-19 Vaccine	PHASE2/PHASE3	WITHDRAWN
Phase III Study of UBT251 Injection in Patients With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Diet and Exercise Alone（UNIGUIDE-1）	PHASE3	NOT_YET_RECRUITING
A Study Evaluating the Efficacy and Safety of Momelotinib in Participants With Vacuoles, E1-enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) Syndrome	PHASE2/PHASE3	NOT_YET_RECRUITING
A Single-patient Clinical Trial of MAS825 in a Patient With XIAP Deficiency	PHASE3	COMPLETED
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy	PHASE2	ACTIVE_NOT_RECRUITING
Determining the Feasibility of MLN9708 as Maintenance After Allogeneic Stem Cell Transplant for Multiple Myeloma	PHASE2	COMPLETED
Tandutinib in Treating Patients Who Have Undergone Surgery for Metastatic Kidney Cancer	PHASE2	COMPLETED
UB-621, a New Type of Anti-herpes Simplex Virus (HSV) Monoclonal Antibody for the Use in the Treatment of Adult Recurrent HSV-2 Infections of the Genitals	PHASE2	UNKNOWN
Personalized Antisense Oligonucleotide for a Single Participant With MAPK8IP3 Neurodevelopmental Disorder With or Without Variable Brain Abnormalities (NEDBA)	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
MLN0128 in Recurrent/Metastatic Merkel Cell Carcinoma	PHASE1/PHASE2	COMPLETED
A Research Study on How Well Different Doses of the Medicine UBT251 Help People Living With Overweight or Obesity	PHASE2	RECRUITING
Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma	PHASE2	SUSPENDED
Studying TAK-243 in Patients With Advanced Cancer	PHASE1	RECRUITING
Dose Escalation Study of Nelfinavir Plus MLN9708 in Patients With Advanced Solid Tumors or Lymphoma	PHASE1	WITHDRAWN
A Study to Evaluate the Ability of UB-612 COVID-19 Vaccine to Boost Immunity of Heterologous COVID-19 Vaccines.	PHASE1	WITHDRAWN
MLN9708 and Vorinostat in Patients With Advanced p53 Mutant Malignancies	PHASE1	COMPLETED
Study to Evaluate Safety, Tolerability, and Pharmacokinetics of UB-621 in Healthy Volunteers	PHASE1	COMPLETED
A Study of MLN8237, a Novel Aurora A Kinase Inhibitor, in Participants With Advanced Solid Tumors	PHASE1	COMPLETED
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck	PHASE1	COMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors	nan	NOT_YET_RECRUITING
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure	nan	COMPLETED
Evaluation of Prognostic Factors: From Breast Cancer to Bone Metastases	nan	UNKNOWN
Evaluating Cascade Communication Methods	nan	COMPLETED
The Role of RING Ubiquitin Ligases in Biologic and Oncologic Processes in Tissues of Mesenchymal Origin	nan	UNKNOWN
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
Establishment of a Prospective Clinical-biological Database	nan	RECRUITING
Identification of a New Blood Biomarker for the Diagnosis and Prognosis of Liposarcomas	nan	RECRUITING
Prognostic Value of Combined Approach Based on KEAP1/NFE2L2 Mutations and Pre-therapeutic FDG-PET/CT Radiomic Analysis in Advanced Non-small-cell Lung Cancer PDL1 ≥ 50% Treated With Pembrolizumab (PEMBROMIC)	nan	UNKNOWN
Von Hippel-Lindau (VHL): Clinical Manifestations, Diagnosis, Management and Molecular Bases of Inherited Renal and Other Urologic Malignant Disorders	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a NEDD8 binder may also engage these)

Protein	Name	Similarity
Q4PLJ0	—	1.000	Q4PLJ0 →
P61282	—	1.000	P61282 →
P29595	—	1.000	P29595 →
Q71UE8	—	1.000	Q71UE8 →
Q93725	—	1.000	Q93725 →
O14399	—	1.000	O14399 →
Q9VJ33	—	0.999	Q9VJ33 →
Q54XV3	—	0.993	Q54XV3 →
Q03919	—	0.991	Q03919 →
O65381	—	0.987	O65381 →
P0C032	—	0.987	P0C032 →
Q8RUC6	—	0.983	Q8RUC6 →
Q9SHE7	—	0.979	Q9SHE7 →
P0C073	—	0.979	P0C073 →
P0C030	—	0.977	P0C030 →
P0C031	—	0.975	P0C031 →
P14797	—	0.968	P14797 →
O02741	—	0.961	O02741 →
P61959	—	0.960	P61959 →
Q2PFW2	—	0.960	Q2PFW2 →
Q6DI05	—	0.960	Q6DI05 →
Q6NV25	—	0.960	Q6NV25 →
Q6LDZ8	—	0.960	Q6LDZ8 →
P61957	—	0.960	P61957 →
Q54TK0	—	0.959	Q54TK0 →
A7WLI0	—	0.958	A7WLI0 →
Q6GPW2	—	0.958	Q6GPW2 →
Q64339	—	0.958	Q64339 →
Q6DHL4	—	0.958	Q6DHL4 →
ISG15	Ubiquitin-like protein ISG15 (Interferon-indu	0.957	landscape →