Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.37 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166359 | 0.91 | P2RX3 (0.40) | KMT2AP2RX3P2RX2TP53TSHR | |
| SCHEMBL18166286 | 0.88 | ROCK1 (0.40) | KMT2AP2RX3P2RX2TDP1LMNA | |
| SCHEMBL18166303 | 0.88 | ROCK1 (0.39) | KMT2AP2RX3P2RX2TSHRCTSK | |
| SCHEMBL18166309 | 0.88 | KMT2A (0.46) | KMT2AP2RX3P2RX2TP53TSHR | |
| SCHEMBL10243307 | 0.87 | P2RX3 (0.48) | P2RX3P2RX2TP53TSHRMAPT | |
| SCHEMBL18166301 | 0.87 | P2RX3 (0.51) | P2RX3P2RX2 | |
| SCHEMBL18166454 | 0.87 | KMT2A (0.36) | KMT2AP2RX3P2RX2MAPTTDP1 | |
| SCHEMBL18036350 | 0.84 | KMT2A (0.39) | KMT2AP2RX3P2RX2TP53TSHR | |
| SCHEMBL18166449 | 0.83 | ACKR3 (0.38) | MAPK1 | |
| SCHEMBL18036370 | 0.80 | P2RX3 (0.37) | KMT2AP2RX3P2RX2TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-B1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-10-26 | — | — | EP | claimed |