Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 2/20 | 0.40 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166449 | 0.93 | ACKR3 (0.38) | MAPK1 | |
| SCHEMBL18166312 | 0.91 | KMT2A (0.40) | P2RX3P2RX2KMT2AMAPTTDP1 | |
| SCHEMBL18166301 | 0.90 | P2RX3 (0.51) | P2RX3P2RX2 | |
| SCHEMBL18166377 | 0.88 | KMT2A (0.44) | P2RX3P2RX2KMT2AKDM4EPOLB | |
| SCHEMBL10243090 | 0.88 | P2RX3 (0.52) | P2RX3P2RX2KDM4EPOLBMAPT | |
| SCHEMBL18166454 | 0.86 | KMT2A (0.36) | P2RX3P2RX2KMT2AKDM4EPOLB | |
| SCHEMBL18166345 | 0.86 | WDR5 (0.44) | KMT2AKDM4EPOLBMAPTNCOA1 | |
| SCHEMBL18166286 | 0.86 | ROCK1 (0.40) | P2RX3P2RX2KMT2ATDP1LMNA | |
| SCHEMBL18166303 | 0.85 | ROCK1 (0.39) | P2RX3P2RX2KMT2AUSP2TSHR | |
| SCHEMBL18166443 | 0.85 | MARS1 (0.43) | KMT2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-B1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-10-26 | — | — | EP | claimed |