Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 3/20 | 0.41 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.38 |
| ▸ | PORCN | Q9H237 | 3/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.32 |
| ▸ | PRCP | P42785 | 1/20 | 0.32 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166342 | 0.88 | P2RX3 (0.41) | P2RX3P2RX2LMNATP53HSP90AA1 | |
| SCHEMBL18166279 | 0.87 | P2RX3 (0.42) | P2RX3P2RX2LMNATP53HSP90AA1 | |
| SCHEMBL18166328 | 0.86 | P2RX3 (0.41) | P2RX3P2RX2LMNATP53HSP90AA1 | |
| SCHEMBL10243836 | 0.86 | P2RX3 (0.55) | P2RX3P2RX2ROCK2ROCK1MAPK1 | |
| SCHEMBL18166362 | 0.85 | P2RX3 (0.41) | P2RX3P2RX2LMNATP53HSP90AA1 | |
| SCHEMBL18166278 | 0.85 | P2RX3 (0.41) | P2RX3P2RX2LMNATP53HSP90AA1 | |
| SCHEMBL18166315 | 0.85 | P2RX3 (0.40) | P2RX3P2RX2LMNATP53HSP90AA1 | |
| SCHEMBL18166439 | 0.84 | P2RX3 (0.39) | P2RX3P2RX2ROCK2ROCK1LMNA | |
| SCHEMBL18166432 | 0.84 | P2RX3 (0.59) | P2RX3P2RX2 | |
| SCHEMBL18166374 | 0.84 | P2RX3 (0.59) | P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-B1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-10-26 | — | — | EP | claimed |