Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 2/20 | 0.41 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.32 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166450 | 0.88 | P2RX3 (0.54) | P2RX3P2RX2POLBSMN1; SMN2GAA | |
| SCHEMBL18166396 | 0.88 | P2RX3 (0.39) | P2RX3P2RX2POLBSMN1; SMN2GAA | |
| SCHEMBL18166339 | 0.88 | P2RX3 (0.48) | P2RX3P2RX2POLBSMN1; SMN2GAA | |
| SCHEMBL18166418 | 0.87 | P2RX3 (0.39) | P2RX3P2RX2POLBSMN1; SMN2GAA | |
| SCHEMBL18166451 | 0.87 | P2RX3 (0.45) | P2RX3P2RX2POLBSMN1; SMN2GAA | |
| SCHEMBL18166324 | 0.86 | P2RX3 (0.37) | P2RX3P2RX2SMN1; SMN2NPC1HCRTR1 | |
| SCHEMBL10243326 | 0.86 | P2RX3 (0.55) | P2RX3P2RX2POLBSMN1; SMN2GAA | |
| SCHEMBL18166300 | 0.86 | P2RX3 (0.46) | P2RX3P2RX2POLBSMN1; SMN2GAA | |
| SCHEMBL18166348 | 0.85 | P2RX3 (0.41) | P2RX3P2RX2MAPTLMNATP53 | |
| SCHEMBL18166279 | 0.84 | P2RX3 (0.42) | P2RX3P2RX2MAPTLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-B1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-10-26 | — | — | EP | claimed |