Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.53 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.31 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | AKT2 | P31751 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.31 |
| ▸ | PRKX | P51817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166319 | 0.90 | P2RX3 (0.53) | P2RX3P2RX2ROCK1ROCK2MAPT | |
| SCHEMBL18166424 | 0.89 | P2RX3 (0.54) | P2RX3P2RX2MAPTACACBTRPV1 | |
| SCHEMBL18166293 | 0.89 | P2RX3 (0.57) | P2RX3P2RX2ROCK1ROCK2CYP3A4 | |
| SCHEMBL18166465 | 0.89 | P2RX3 (0.52) | P2RX3P2RX2ROCK1ROCK2MAPT | |
| SCHEMBL10243736 | 0.87 | P2RX3 (0.70) | P2RX3P2RX2ROCK1ROCK2CYP3A4 | |
| SCHEMBL18166427 | 0.87 | P2RX3 (0.55) | P2RX3P2RX2ROCK1ROCK2CYP3A4 | |
| SCHEMBL18166335 | 0.85 | P2RX3 (0.59) | P2RX3P2RX2MAPTLMNA | |
| SCHEMBL18166450 | 0.85 | P2RX3 (0.54) | P2RX3P2RX2MAPTTRPV1LMNA | |
| SCHEMBL18166400 | 0.84 | P2RX3 (0.61) | P2RX3P2RX2MAPTLMNA | |
| SCHEMBL18166272 | 0.84 | P2RX3 (0.47) | P2RX3P2RX2ROCK2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-B1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-10-26 | — | — | EP | claimed |