Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 5/20 | 0.36 |
| ▸ | P2RX2 | Q9UBL9 | 5/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PRKCG | P05129 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | AKT2 | P31751 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166268 | 0.88 | P2RX3 (0.49) | P2RX3P2RX2 | |
| SCHEMBL10243796 | 0.87 | P2RX3 (0.48) | P2RX3P2RX2AKR1C3AKR1C2KDM1A | |
| SCHEMBL18166394 | 0.86 | ROCK1 (0.38) | P2RX3P2RX2AKR1C3AKR1C2RPS6KA5 | |
| SCHEMBL18036417 | 0.86 | P2RX3 (0.44) | P2RX3P2RX2PTGS2FAAH | |
| SCHEMBL18166460 | 0.86 | AKR1C3 (0.38) | P2RX3P2RX2AKR1C3AKR1C2RPS6KA5 | |
| SCHEMBL18166284 | 0.84 | MAP3K5 (0.35) | P2RX3P2RX2PTGS2 | |
| SCHEMBL18166279 | 0.82 | P2RX3 (0.42) | P2RX3P2RX2 | |
| SCHEMBL18166380 | 0.82 | P2RX3 (0.48) | P2RX3P2RX2 | |
| SCHEMBL18166349 | 0.82 | P2RX3 (0.48) | P2RX3P2RX2 | |
| SCHEMBL18166347 | 0.80 | P2RX3 (0.47) | P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-B1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-10-26 | — | — | EP | claimed |