Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.39 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.38 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL18167285 | 0.84 | MAPT (0.39) | RAB9ANPC1SMN1; SMN2MAPTKDM4E | |
| Bicarbonate SCHEMBL18167209 | 0.83 | LPAR1 (0.38) | RAB9ANPC1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL3638 | 0.82 | LPAR1 (0.58) | RAB9ALMNANPC1SMN1; SMN2TP53 | |
| Bicarbonate SCHEMBL18167184 | 0.81 | DHODH (0.42) | LPAR1LPAR3STAT1MEN1KMT2A | |
| Bicarbonate SCHEMBL18167284 | 0.81 | IP6K1 (0.42) | MAPTKDM4EIP6K1IP6K3IP6K2 | |
| Bicarbonate SCHEMBL18167206 | 0.80 | HSD17B1 (0.43) | LMNANPC1MAPTKDM4ELPAR1 | |
| Bicarbonate SCHEMBL18167200 | 0.79 | DHODH (0.41) | MAPTKDM4EKDR | |
| SCHEMBL10152 | 0.74 | ABCC3 (0.49) | RAB9ALMNANPC1SMN1; SMN2TP53 | |
| Bicarbonate SCHEMBL18167219 | 0.74 | MAPT (0.38) | RAB9ANPC1SMN1; SMN2MAPTKDM4E | |
| Bicarbonate SCHEMBL18167224 | 0.73 | ENPP2 (0.39) | RAB9ANPC1MAPTKDM4ELPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483251-B1 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS INC (US) | 2016-10-26 | — | — | EP | claimed |