Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PYGL | P06737 | 2/20 | 0.35 |
| ▸ | PYGM | P11217 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | DDO | Q99489 | 1/20 | 0.34 |
| ▸ | MAP2 | P11137 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22198970 | 0.80 | HRH4 (0.45) | HRH4IDH1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL22185228 | 0.77 | HRH4 (0.43) | HRH4IDH1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL3361624 | 0.77 | DAO (0.58) | HRH4DAODDO | |
| SCHEMBL21549766 | 0.76 | IDH1 (0.49) | HRH4IDH1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL17601436 | 0.74 | IDH1 (0.47) | HRH4IDH1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL30064708 | 0.74 | IDH1 (0.47) | HRH4IDH1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL20003973 | 0.74 | HRH4 (0.40) | HRH4IDH1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL17601439 | 0.74 | IDH1 (0.47) | HRH4IDH1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL18744798 | 0.73 | HRH4 (0.40) | HRH4IDH1GRIN2DGRIN3BGRIN1 | |
| Hydrochloric Acid SCHEMBL17601106 | 0.73 | IDH1 (0.47) | HRH4IDH1GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016171756-A1 | QUINOLINONE FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2016-10-27 | — | — | WO | claimed |