Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.43 |
| ▸ | IDH1 | O75874 | 5/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 6/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 6/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 6/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 6/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PYGL | P06737 | 1/20 | 0.35 |
| ▸ | PYGM | P11217 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18744798 | 0.86 | HRH4 (0.40) | HRH4IDH1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL22198970 | 0.80 | HRH4 (0.45) | HRH4IDH1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL22185211 | 0.79 | TNF (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL22185229 | 0.78 | IDH1 (0.57) | IDH1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL18171730 | 0.77 | HRH4 (0.43) | HRH4IDH1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL22185397 | 0.77 | IDH1 (0.43) | IDH1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3361624 | 0.77 | DAO (0.58) | HRH4DAO | |
| SCHEMBL21549766 | 0.76 | IDH1 (0.49) | HRH4IDH1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL17601436 | 0.74 | IDH1 (0.47) | HRH4IDH1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL30064708 | 0.74 | IDH1 (0.47) | HRH4IDH1GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200206233-A1 | HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS | INTEGRAL BIOSCIENCES PRIVATE LIMITED (IN) | 2020-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200206233-A1 | HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS | IDH1, IDH2, IDH3A | HRH4 1283/4885IDH1 1/4885GRIN2D 2691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.