Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 4/20 | 0.44 |
| ▸ | TPH1 | P17752 | 2/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | FAP | Q12884 | 2/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | GRB2 | P62993 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18171811 | 1.00 | TDP1 (0.44) | TDP1DPP4TPH1SLC7A5TRPA1 | |
| SCHEMBL28097095 | 0.84 | SLC7A5 (0.44) | TDP1SLC7A5ALPIPKMPTGS1 | |
| SCHEMBL10435928 | 0.84 | SLC7A5 (0.62) | DPP4SLC7A5ALPIPKMPTGS1 | |
| SCHEMBL29964940 | 0.83 | TDP1 (0.46) | TDP1DPP4TPH1SLC7A5FAP | |
| Hydrochloric Acid SCHEMBL6164908 | 0.83 | SLC7A5 (0.43) | TDP1DPP4TPH1SLC7A5DPP8 | |
| Hydrochloric Acid SCHEMBL6165185 | 0.83 | SLC7A5 (0.61) | DPP4SLC7A5ALPIPKMPTGS1 | |
| Hydrochloric Acid SCHEMBL6164900 | 0.83 | SLC7A5 (0.43) | TDP1DPP4TPH1SLC7A5DPP8 | |
| Hydrochloric Acid SCHEMBL6165180 | 0.83 | SLC7A5 (0.61) | DPP4SLC7A5ALPIPKMPTGS1 | |
| SCHEMBL1764633 | 0.82 | ALPI (0.63) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL30959049 | 0.82 | ALPI (0.63) | SLC7A5ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180072997-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | BRISTOL-MYERS SQUIBB COMPANY | 2018-03-15 | — | — | US | disclosed |
| EP-3286174-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV Healthcare UK (No.5) Limited (GB) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016172425-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV HEALTHCARE (NO.5) LIMITED (GB) | 2016-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180072997-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | EIF2AK2, POLR2H, POLR2E | TDP1 1280/4885DPP4 3366/4885TPH1 2775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.