Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL782035 | 0.87 | TLR2 (0.38) | PABPC1ROCK2DPP4 | |
| SCHEMBL782189 | 0.85 | SCN4A (0.41) | HDAC8ROCK2 | |
| SCHEMBL780473 | 0.78 | AKT1 (0.40) | EPHX1PTGES | |
| SCHEMBL18945036 | 0.75 | EPHX1 (0.42) | EPHX1CYP1A2ALDH1A1 | |
| SCHEMBL18945327 | 0.75 | EPHX1 (0.42) | EPHX1CYP1A2ALDH1A1 | |
| SCHEMBL18171881 | 0.69 | PDGFRB (0.61) | LMNAHTTSMN1; SMN2CCNCCDK8 | |
| SCHEMBL1598483 | 0.69 | BACE1 (0.57) | HTTPABPC1TLR9CYP1A2PIK3R1 | |
| SCHEMBL23093847 | 0.69 | PABPC1 (0.39) | LMNAHTTSMN1; SMN2PABPC1CYP1A2 | |
| SCHEMBL29688067 | 0.69 | PABPC1 (0.39) | LMNAHTTSMN1; SMN2PABPC1CYP1A2 | |
| SCHEMBL18171875 | 0.69 | HTT (0.46) | LMNAHTTSMN1; SMN2CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016170163-A1 | SUBSTITUTED QUINOXALINES AND BENZOTRIAZINE P70S6 KINASE INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2016-10-27 | — | — | WO | disclosed |